Via Clássica da Apoptose → Via Extrínseca Flashcards

1
Q

​Via Extrínseca

A

Nossas células → tem receptores da morte.

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2
Q

Via Extrínseca - Receptores da Morte 3

A

TNFR

TRAILR

Fas

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3
Q

​TNFR → ?

TRAILR → ?

Fas → ?

A

​TNFR → Receptor para o fator de necrose tumoral

TRAILR → Receptor do ligante indutor de Apoptose relacionado com o fator de necrose tumoral

Fas → Primeiro sinalizador da Apoptose / First apoptosis signal

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4
Q

Via Extrínseca - Indução

A

Estressores se ligam aos receptores.

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5
Q

Via Extrínseca - Indução → Estressores 3

A

TNFalfa

TRAIL

Fas Lig

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6
Q

Ligação Estressor + Receptor → Resultado

A

Formação de um Produto Intermediário.

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7
Q

Produtos Intermediários

TNFalfa → ?

TRAIL → ?

Fas Lig → ?

A

Produtos Intermediários

TNFalfa → TRADD

TRAIL → FADD

Fas Lig → Procaspase 8

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8
Q

Produtos Intermediários → O que fazem?

A

Induzem uma enzima → Caspase 8

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9
Q

Caspase 8 → O que faz?

A

Ativa a Caspase 3

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10
Q

Caspase 3 → O que faz?

A

Leva à apoptosis.

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11
Q

Via Extrínseca → ?

A

Via Extrínseca → ativa receptor da morte → enzima Caspase 8 ativada → Apoptose → morte.

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