VetNeuroJAR Flashcards
How is the Western Equine Encephalitis Virus (WEEV) primarily transmitted?
A. Through contaminated water
B. Through the bite of infected mosquitos
C. Through contact with infected birds
D. Through contact with infected horses
B. Bite of infected (ornitophilic) mosquitos.
Culex tarsalis in North Am.
Genus Mansonia sp. in Argentina.
Which of the following is NOT a symptom of WEEV infection in horses?
A. Fever B. Anorexia C. Respiratory distress D. Encephalomyelitis
C. Respiratory distress
What was the approximate fatality rate of WEEV in horses during the 2023-2024 outbreak?
A. 100% B. 85% C. 50% D. Data unavailable in the source
D. Data unavailable.
It says “high”.
According to the phylogenetic analysis in the study, the WEEV strains from the 2023-2024 South America outbreak are:
A. Genetically similar to North American WEEV strains.
B. Likely part of a novel WEEV lineage.
C. Genetically diverse and unrelated to other WEEV strains.
D. Identical to strains from the 1982-1983 outbreak in Argentina.
B. Likely part of a novel WEEV lineage.
Which of the following neural autoantibodies was detected in the dogs diagnosed with IGTS?
A. LGl1
B. NMDAR
C. mGluR1
D. GABA-A-R
Kajin and Volk 2024
C) mGluR1
In 2 dogs.
What is the most common treatment for canine idiopathic generalized tremor syndrome (IGTS) in dogs?
A. Antibiotics
B. Anticonvulsants
C. Corticosteroids
D. Physical therapy
C) Corticosteroids.
What is the most common route of Neospora caninum infection in dogs?
A. Ingestion of infected tissue from intermediate hosts.
B. Ingestion of oocysts in feces.
C. Vertical transmission via the transplacental route.
D. Horizontal transmission through contact with infected dogs.
C) Vertical transmission.
Leads to the formation of bradyzoite cysts and clinical disease sporadically. A and B are also possible.
What was the median age of onset of clinical signs in the dogs studied?
A. 8 months B. 10 years C. 2.5 years D. 6 months
C) 2.5 years.
Which of the following is NOT a common clinical sign of adult-onset neosporosis in dogs?
A. Generalized myopathy B. Myelopathy C. Hepatomegaly D. Intracranial disease
C) Hepatomegaly
What percentage of dogs in the study experienced at least one relapse of neosporosis?
A. 100% B. 62% C. 38% D. 19%
19%.
What percentage of rabies-positive animals present Negri bodies in their brains?
A. 10 - 20%
B. 25 - 50%
C. 53.7 - 70%
D. 80 - 90%
C) 53.7 - 70%
They are unique to rabies, and have different sizes (1-27 microm) and shape.
What type of virus is the rabies virus?
A. DNA virus
B. RNA virus
C. Retrovirus
D. Adenovirus
b) RNA virus
Belongs to the genus Lyssavirus and family Rhabdoviridae.
What is the gold standard for rabies antigen detection?
A. Hematoxylin and eosin (HE) stain
B. Seller’s stain
C. Immunohistochemistry (IHC)
D. Direct fluorescent antibody test (dFAT)
d) Direct fluorescent antibody test (dFAT)
HE and Seller’s stain: unable to distinguish Negri bodies from Negri-like inclusion bodies, therefore no longer recommended.
In the study discussed in the source, which area of the brain was found to have the highest prevalence of Negri bodies?
A. Cerebrum
B. Thalamus
C. Brainstem
D. Hippocampus
d) Hippocampus (87.14%)
Followed by cerebrum (70%), and thalamus (2.86%). No detection in the brainstem.
What was the most common MRI finding in dogs with SRMA in the study?
A. Meningeal contrast enhancement
B. Spinal cord parenchymal T2-W hyperintensity
C. Paravertebral muscle changes
D. Hemorrhage
C) Paravertebral muscle changes (56.6%)
Followed by meningeal contrast enhancement (31.7%) and spinal cord parenchymal T2-W hyperintensity (28.3%).
Which of the following clinical signs was significantly associated with the presence of T2-W spinal cord hyperintensity and hemorrhage in dogs with SRMA?
A. Pyrexia
B. Cervical hyperesthesia
C. Paresis/Paralysis
D. Relapse
C) Paresis/paralysis
All dogs with paresis/paralysis had identifiable spinal cord parenchymal lesions or meningeal enhancement.
According to the study, which of the following is a possible reason for the lower prevalence of meningeal contrast enhancement observed compared to previous studies?
A. The use of only a single T1-W series obtained immediately post-contrast
B. The higher proportion of low-field MRI studies in the current study
C. The lack of a post-processing subtraction technique
D. The inclusion of dogs with milder disease in the current study
A) The use of only a single T1-W post op.
Several were only examined in the sagittal plane.
What is the suspected reason for hemorrhage in dogs with SRMA?
A. Trauma
B. Intervertebral disc disease
C. Neoplasia
D. Rupture of vessels secondary to severe inflammation
D) Rupture of vessels secondary to severe inflammation
And/or thrombosis. Other differential dx are trauma, IVDD, neoplasia…
Effect of midline shift on survivaltimewith structural brain dz dx onMRI
What was the primary objective of the research study discussed in the article?
A. To compare the effectiveness of different treatment protocols for structural brain disease in dogs.
B. To evaluate the impact of midline shift on survival time in dogs with structural brain disease diagnosed using MRI.
C. To determine the prevalence of structural brain lesions in different dog breeds.
D. To investigate the correlation between midline shift and the development of seizures in dogs.
B) To evaluate the impact of midline shift on survival time in dogs with structural brain disease diagnosed using MRI.
According to the study, what is the median survival time for dogs with structural brain disease who present with a midline shift?
A. 241 days B. 34.5 days C. 90 days D. 1460 days
B) 34.5 days.
Compared with 241 days in dogs without midline shift.
Which of the following imaging findings was NOT found to be a significant factor contributing to an increased risk of death in dogs with structural brain disease?
A. Midline shift
B. Foramen magnum herniation
C. Brain edema
D. Ventriculomegaly
All except A
Foramen magnum herniation, brain edema and ventriculomegaly did not achieve significance.
What was one of the limitations of the study acknowledged by the authors?
A. The study was prospective in nature, leading to potential bias in data collection.
B. A greater proportion of dogs with neoplasia and midline shift were euthanized within 24 hours of diagnosis, potentially skewing survival times.
C. The study included a large and diverse cohort of dogs with various diagnoses.
D. Standardized imaging and treatment protocols were strictly adhered to throughout the study.
B) A greater proportion of dogs were euthanized within 24 hours.
What was the primary treatment approach for the dog’s condition?
A. Antibiotics
B. Surgery
C. Immunosuppressive therapy
D. Physical therapy
Clinical signs, diagnostic imaging, histopathology and outcome in a dog with meningoencephalomyelitis of unknown origin and concurrent involvement of the cauda equina and left sciatic nerve
c) Immunosuppressive therapy.
What was a significant finding regarding the dog’s MUO that was highlighted in the case report?
A. The dog’s breed was not typically associated with MUO.
B. The dog’s condition did not respond to immunosuppressive treatment.
C. The dog’s MUO involved the peripheral nervous system (PNS), specifically the sciatic nerve.
D. The dog did not experience any relapses after the initial diagnosis.
Clinical signs, diagnostic imaging, histopathology and outcome in a dog with meningoencephalomyelitis of unknown origin and concurrent involvement of the cauda equina and left sciatic nerve
C. The dog’s MUO involved the peripheral nervous system (PNS), specifically the sciatic nerve.
What is the most common treatment regimen for MUO in dogs?
A. Long-term glucocorticosteroid application.
B. A combination of procarbazine and prednisone.
C. Mycophenolate mofetil and corticosteroids.
D. Parenteral cytarabine in conjunction with long-term glucocorticosteroids.
D. Parenteral cytarabine in conjunction with long-term glucocorticosteroids.
Which of the following is NOT a challenge hindering the understanding of MUO in dogs?
A. The ambiguity regarding whether all MUO subtypes constitute a single disease entity or represent distinct diseases with varying etiopathogenesis.
B. Uncertainties regarding the autoimmune nature of these diseases or the potential involvement of an infection triggering and initiating excessive inflammation.
C. A lack of reliable diagnostic biomarkers to establish the diagnosis of MUO or distinguish between subtypes.
D. The significantly higher prevalence of MUO in cats compared to dogs.
D. The significantly higher prevalence of MUO in cats compared to dogs.
What cytokine is found in significantly increased serum levels in dogs with MUO, particularly those with GME?
A. IFN-γ.
B. IL-10.
C. IL-31.
D. CX3CL1.
C) IL-31.