Veterinary Immunology Case Studies

Question 1

Case #1- Cyclic Neutropenia

Answer 1

episodes of infection when peripheral neutrophil counts fall to less than 1000/microliter. Occurs at 10-12 day intervals. Mutation in a gene causes a defect in the granulocyte colony stimulating factor signal transduction pathway. Treatment: inject recombinant G-CSF resulting in normalization of the leukocyte production cycle

Question 2

Case #2- calf with pneumonia that has a lot of circulating neutrophils but few in lung tissue

Answer 2

genetic mutation resulting in nonfunctional leukocyte integrin preventing neutrophils from adhering to vessel wall and migrating.

Question 3

Case #3- persistent cough with high RR. Red bronchial mucosa

Answer 3

Ciliary Dyskinesis- no movement

Question 4

Case #4- Chediak-Higashi Syndrome

Answer 4

neutrophil lysosomes are larger than normal and abnormal in function.