Vet Sci 2 Flashcards
True or false
During absorption the drug will pass from the site of administration into systemic circulation
True
True or false
The dosage of the drug is the total amount of a given at one time, expressed in mls, cc’s, tablets, etc.
False
Dose
True or false
A/an enterostomy bypasses the oral cavity and esophagus and goes directly into the stomach from the outside of the body
False
Gastrotomy
True or false
a diagnostic indication for performing an abdominocentesis would be to evaluate peritoneal fluid
True
True or false
a common injection site for an epidural and a small animal is between L7 and S1
True
True or false
with a subconjunctival injection, the needle is placed in the anterior chamber of the eye
False
under the bulbar conjunctiva
True or false
one diagnostic indication for an intrathecal injection is to obtain CSF for evaluation and analysis
True
True or false
Lipophilic drugs are attached to the phospholipid cell membrane and are best given subcutaneously or intramuscularly
False
Orally
True or false
measurement for placement of an orogastric tube in a cat is from the tip of the nose to the last rib
False
10th or 11th rib
True or false
Fentanyl patches are an example of transdermal medication administration
True
The dosage interval BID for
Twice daily
Every 12 hours
True or false decreasing the dose of a drug for a specific breed or species will not cause a potential toxicity
True
True or false
absorption in distribution are included in the first phase of the pharmacokinetics of drugs?
True
What is the medical term for surgical puncture of a joint
Arthrocentesis
True or false
liver is the primary site of biotransformation of a drug
True
What is the medical term for the amount of blood passing through a tissue or organ
Tissue perfusion
True or false
Lateral saphenous vein should be saved for an indwelling catheter during a blood draw
False
cephalic vein
The prescription label for an offer ophthalmic ointment says it needs to be applied QID to OS. would you tell the owner that this means
Four times daily to the left eye
What is the maximum IM volume for large animals
10cc/site
What is the primary site of elimination in the body
Kidney
What concerns is are there when administering food or medications through and oro- or nasogastric tube
If the tube is passed incorrectly we could cause aspiration pneumonia
Epistaxis can result from placement of a NG tube
True or false
SQ is used for allergy testing in dogs
False
ID
True or false
head of the femur is not a commonly used side for an IO injection
True
When obtaining a fluid sample via the thoracocentesis it is important to place the needle
In the ventral 1/3 of the thorax
When performing an IC injection on a patient, what position should the patient be in
Right lateral recumbency
True or false latex gloves should be worn when administering chemotherapeutic drugs
True
What are indication for using oral forms of medication
Treating a specific G.I. disorder
Ease of at home administration
Protein binding, where a drug binds with a blood protein, happens during which phase of pharmacokinesis
Distribution
What is the dose range for an enema
5ml/lb of BW - 20ml/lb of BW
What are the “five rights” of medication administration
Right route right drug right patient right dose right time
What are two secondary sites of elimination in the body
Sweat glands
liver
What is the medical term for the chemical component formed from biotransformation of a drug
Metabolites
What are two complications of a surgically placed feeding tube
Infection
dislodgment of tube
List the three preferred SQ injection sites and small animals
Lateral thorax
flank
scruff
List 2 indications for topical administration of a medication
Local anesthesia
flea and tick
Give 2 advantages of injectable medication administration
Works faster
less stress
What IM injection site is preferred at Bel-rea
Lumbar
Drug
Any chemical agent that when absorbed into system alters body function
Dosage
Amount of drug per unit of bodyweight
Dose
Amount of drug given at one time
Perfusion of tissues
The amount of blood passing through a tissue or organ (carrying O2 & Hgb)
Metabolites
A chemical component formed from biotransformation of a drug
Primary site of biotransform
Liver
Secondary site of biotransform
Lungs
skin
intestinal track
Primary site of elimination
Kidneys
Secondary site of elimination
Liver
lungs
sweat
mammary glands
Meds that never go SQ
Whole blood
hypertonic solutions
oil-based medications
Lack of resistance a.k.a. vulnerability
Susceptibility
Enhances activation and proliferation of T lymphocytes, B lymphocytes and NKC
Helper T cells
Vaccine that is made up of parts of the virus
Subunit vaccine
Protein that circulates in the bloodstream, becomes active during times of infection, causes lysis of bacterial cells
Complement
Foreign protein
Antigen
Type of subunit vaccine with genetically engineered DNA
Immunogenicity
Ability to provoke an immune response
Immunogenicity
Protien released by the infected cell, protects the surrounding cells by making a protective coat
Interferon
Vaccine in which the pathogen is a similar antigen but incapable of causing disease
Heterologous vaccine
The body mounts an immune response to the presence of an antigen
Active immunity
Protein that attaches to iron, transports iron into bone marrow, depletes the antigen of iron that they need to survive
Transferrin
Headed T cell function, control immune response
Suppressor T cells
Memory antibody, secreted when exposed to an antigen for the second time
IgM
Product developed to stimulate immunity against a disease
Vaccine
Disease producing organism
Pathogen
Killed vaccines that contains two or more antigens related organisms
Polyvalent vx
Immunity produced by administration of a preformed antibody
Passive immunity
What protects an animal from disease causing pathogens
Immunity
Vx that contains a live organism that will replicate in the body selected to stimulate immunity without causing disease
Modified life vaccine
Injection of a vaccine for the purpose of inducing immunity
Vaccination
Killer T cells, attach to antigenic cells and destroy them directly
Cytotoxic T cells
First antibody made by newborns in response to an antigen
IgG
Body’s response to a foreign protein
Antibody
Vx in which organisms have been killed or inactivated by chemical or physical agents
Killed vaccine
Antibody produced in response to an allergic reaction
IgE
True or false
during phagocytosis adherence is the movement of white blood cells into the area of inflammation
False
chemotaxis
True or false
Lymph from the digestive system is known as chyle
True
True or false
an example of passive immunity is vaccination
False
clostrium
True or false
specific immunity is the ability of the body to target and destroy specific antigens and is also known as innate immunity
False
adaptive
True or false
a mild fever (under 103°F) is normal for about 24 hours following a vaccination
True
True or false
killed vaccines should be avoided in pregnant animals
False
MLV
True or false
dogs will have protective antibodies three weeks after receiving in injectable Bordetella vaccine
True
True or false
puppies should have their first distemper combo vaccine at 10 weeks of age
False
6-8 weeks
True or false
the spleen is considered a secondary lymphatic organ
True
True or false
Humoral immunity is also referred to as “antibody mediated” immunity
True
Organisms have been killed or in activated by chemical or physical agents
Killed vaccine
rabies
Type of subunit vaccines where the immunoprotective proteins from the pathogen are removed and inserted into an avirulent vector
DNA-based
west Nile equine
Contains a live organism that has been attenuated so it will stimulate immunity without causing disease
Modified live
distemper
Type of killed vaccine that contains two or more antigens from related organisms
Polyvalent
Leptospirosis
Type of vaccine that is made up of parts of a vaccine
Subunit
FeLV
Type of vaccine in which the pathogen is a similar antigen but will not cause disease
Heterologous
Cow Pox
Occurs within minutes of exposure to antigen, often caused by vaccines
Immediated hypersensitivity
Inflammatory reaction, antibody antigen complexes become trapped and endothelium
Immune complex reaction
Antibodies form against the body’s own blood or tissue cells
Cytotoxic hypersensitivity
Inflammatory reaction (like a TB test) that happens over a period of time
Delayed hypersensitivity
List the five mechanisms of phagocytosis
Chemotaxis adherence ingestion digestion killing
List the six components of the canine distemper vaccine
Distemper hepatitis/adenovirus leptospirosis parainfluenza parvovirus _+/- Corona
There are many causes of vaccine failure. list three
Age
stress
maternal interference
There are many reasons to vaccinate our pets. name one
Protection against transmitted zoonotic disease
Name one disadvantage to using a killed vaccine
Requires more frequent revaccinations
4 things to check prior to administration
Right pt
Right dose
Right route
Right drug
Biotransformation
Happens in the liver
Eliminations of Drugs
Kidneys
Orogastric tube
Stomach tube through the mouth
Measure from mouth to the 13th rib
Nasogastric tube
Through the nose into the stomach
Measure from nose to the 13th rib
Endotracheal tube
Placed via the mouth into the trachea
Used for anesthesia
IV
Intravascular
Best
Fastest absorption
PO
Oral
Slowest absorption
Rectal
Slow absorption
IP
Intraperitoneal
Immediate absorption
IC
Intracardiac
Not used often
Fast absorption
IM
Intramuscular
Intermediate absorption
CAREFUL OF THE SCIATIC NERVE
IM locations
Longissimus dorsi
Biceps femoris
Iliocostalis
SQ
Subcutaneous
Intermediate absorption
Most often used - next to IV
IO
Intraosseous
Fast absorption
Not common to use
IO in birds
Pneumatic bones
Can administer O2 this way
IO Locations
Greater tubercle of the humerus
Trochanteric fossa of the femur
Tibial crest
IN
Intranasal
Bordetella, FIP, Strangles (Step equi), local anesthesia
Proteins
Tissue building
Lipids
Insulation, absorption, protection
Lipoic Acid – leafy green vegetable
Carbohydrates
Soluble
Insoluble – corn, carrots, pumpkin, some vegetables
Taurine
Essential in cats
Deficiency can cause blindness
H2O in the body
Transportation
Solubility
Antioxidants
Substance that can scavenge “free radicals”
Vitamins – C, E, A
Flavonoids
Dietary Fiber
Increases fecal bulk
Essential Fatty Acids
Prevent allergies
Vitamin K
Blood clotting cascade
Calcium
Bone growth
Macromineral
- required in diet in percentage amounts
Vitamin D
Bone growth
Leptospirosis
Bacterin
Polyvalent vx
Distemper
Modified live vx
Given SQ
- right front limb distal to the midscapula
Rabies
Killed vx
- advantage
- -less of abortion
- -easier storage
- disadvantage
- adjuvant
- -increases exposure time
- -cheaper
- -increases immunogenicity
- anaphylaxis
Where and how is rabies given?
SQ
Right hind limb distal to hip joint
Bordetella
Intranasal vx
Can be IM
Cow/Smallpox
Heterologous vx
FeLV
Subunit vx
Where and how is FeLV given?
SQ
Left hind limb distal to the hip joint
Natural Killer Cells
Lymphocytes that have the ability to kill infected tissue cells and tumor cells
4 Signs of Inflammation
Redness Heat Swelling Pain \+/- loss of function
Active Immunity
Vx
Passive Immunity
Colostrum
Spleen functions
Blood storage
Removal of foreign material by macrophages
Filtration and removal of dread/dying RBCs
Transferrin
Antimicrobial protein that binds to iron and moves it into bone marrow
Not available for use by the pathogen
LN: Submandibular
Palpable
Under jaw bone
LN: Prescapular
Palpable
Behind shoulder blade
LN: Axillary
NOT palpable
Armpit
LN: Inguinal
NOT palpable
Groin area
LN: Popliteal
Palpable
In the hind leg
Lymph System Functions
Filtration
Transports dietary lipids
Transports protein
Immunoglobulins: IgA
Able to pass into tissues
Attaches to ag directly at the site
Immunoglobulins: IgG
Passed from mom to neonate in colostrum
First immunoglobulin produced in response to a foreign invasion
Nervous Tunic
Retina
Vascular Tunic
Posterior segment
- tapedum lucidium
- choroid
Fibrous Tunic
Outermost layer
Cornea
Structure found in the anterior portion
Focuses images
Corneal ulcers
Corneal ulcers
Pain
Blpharospasm
Keratitis
Tx: conjunctival flap
Corneoscleral junction
Where the cornea and sclera meet
Vitreous Humor
Thick jelly like substance found in the posterior portion
Aqueous Humor
Produced by the Ciliary Process
Serous fluid
Found in the anterior portion
Sclera
White of the eyeball
Lens
Focuses images Suspensory Ligaments -holds lens in place -also attached to the ciliary body
Canthus
Areas where the eyelids meet
- Lateral
- Medial
Nasolacramal Duct
Duct between the eyes and nose
Tears form from the eye to the sinus
-lacramal puncta
Entropion
Inward deviation of the eyelid
- corneal abreasions
- Keratitis
- -inflammation of the cornea
- –“steamy eye”
Ectropion
Outward deviation of the eyelid
-bloodhounds, bull dogs
Enophthalmos
Inward turning of the eyeball -sinking of the eyeball Caused by acute corneal pain Absorption of post-orbital fat Dehydration Anterior uveitis
“Cherry Eye”
Protrusion of the gland of the 3rd eyelid
Nictitating Membrane
3rd eyelid
Photoreceptors: Rods
Interpreting shapes
Photoreceptors: Cones
interpreting color
Mydriasis
Dilated pupil
Myosis
Constricted pupil
Anisocoria
Pupils of unequal size
Ophthalmoscope
Used to examine the fundus of the eyes
- also will see
- -choroid
- -optic disc
Schiotz Tonometery
Dx glaucoma
-tx with miotic drops and maybe cryosurgery
Normal range
-12-24 mmHg
Menace Test
Bring something to eye quickly and see if they blink
If so, positive result
Chalazion
Blocked Meibomian gland
-tx with warm compress
Tapedum Lucidium
Reflective layer in the back of eye
Aids in night vision
Synechia
Adhesion of the iris to either the cornea or lens
Pannus
Autoimmune disorder where pigment is deposited on the surface of the cornea
Pannus tx
Keratectomy
Keep out of UV light
Epiphora
Overflow of tears onto the fur
Accomodation
Contraction and relaxation of the suspensory ligament
Copora Nigra
Extension of the iris to protect from direct sunlight
Blepharospasm
Sudden, involuntary spasm of the eyelids
Hypopyon
Pus in the anterior chamber
Pectin
Thin, ribbon like structure extending from the choroid into the vitreous humor in BIRDS
Photoemulsification
Surgery treatment of cataracts
Tests Performed
Gross exam
Pupillary light reflex (PLR) test
Scirmer Tear Test
Dx test to determine if pt has KCS
- keratoconjunctivitis sicca
- normal reading - 17-22 mm in 1 minute
Flourescein Test
Drops of flourescein dye into eye
- green dye
- see if it comes out the nose
Mydriatic Drops
Dilates pupils
Periodental Probe
measuring gingival sulcus
Extraction Forceps
Used to chip off pieces of tartar
Pulls teeth
Hand Scaler
Removes tartar/plaque from the crown of the tooth
Periodontal Curette
Removes subgingival tartar/plaque
Carnasial Teeth
Premolar 4
Upper and lower
Has 3 roots
Permanent Teeth
In by 4-6 months
-can be up to 9 months
At what ages do we commonly vaccinate puppies?
6-8 weeks
12 weeks
16 weeks
Give the location of canine vaccine admin
SQ, right front limb distal to mid-scapula
Give the location of rabies vaccine admin
SQ, right hind limb distal to hip
Give the location of a FeLV vaccination
Left hind limb distal to hip joint