Vesiculobullous blistering Flashcards
what is the primary feature of immunobullous disorders
blisters
what is nikosky’s sign
the top layers of the skin slip away from each other when rubbed gently
what is nikosky’s sign postive
pemphigus vulgaris
pemphigus vulgaris
produces fragile fluid filled blisters that rupture to form shallow erosions
where is the split in pemphigus vulgaris
superficial and intraepidermal
where does pemphigus vulgaris typically effect
scalp, face, axillae and groin and oral area.
mucosal involvement eg eyes, genitals common
what is there a risk of when lesions rupture
infection 2y
pemphigus vulgaris pathpphysiology
- IgG antibodies made against desmoglein 3, immune complexes form and results in loss of intercellular connections (desmosomes). This results in loss of cohesion between keratinocytes – ACANTHOLYSIS
where is desmoglein 3 found
found in keratinocytes
Bullous Pemphigoid usually presents in
elderly , background of dermatitis or normal skin
Bullous Pemphigoid
dense blisters and erosions
where is the split in Bullous Pemphigoid
through DEJ
do Bullous Pemphigoid heal with/out scarring
without scarring
what is the prebullous period in Bullous Pemphigoid
can be prolonged - persistent pruritic urticated plaques or eczema precedes blisters
does mucous involvement occur in Bullous Pemphigoid
in about 20% cases
what are hemidesmosomes
The hemidesmosomes are found in the BM zone of epidmermis of skin and act to keep the epidermis attached to the dermis normally
