Vent+Gas exchange Flashcards

1
Q

How would you describe these lungs?

A

Normothermic ex-vivo ventilated perfused lungs

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2
Q

def Alveolar ventilation (Valv)

A

The volume of air reaching the respiratory zone per minute

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3
Q

def Respiration

A

The process of generating ATP either with an excess of oxygen (aerobic) and a shortfall (anaerobic)

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4
Q

Physiological dead space

A

Equivalent to the sum of alveolar and anatomical dead space

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5
Q

def Hypoventilation

A

Deficient ventilation of the lungs; unable to meet metabolic demand (increased PO2 – acidosis)

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6
Q

def Hyperventilation

A

Excessive ventilation of the lungs atop of metabolic demand (results in reduced PCO2 - alkalosis)

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7
Q

def Hyperpnoea

A

Increased depth of breathing (to meet metabolic demand)

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8
Q

def Apnoea

A

Cessation of breathing

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9
Q

def Dyspnoea

A

Difficulty breathing

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10
Q

def Bradypnoea

A

Slow breathing rate

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11
Q

def Orthopnoea

A

Positional difficulty in breathing (when lying down)

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12
Q
A

Left>Right
Inspiratory reserve volume
Expiratory reserve volume
Tidal volume
Residual volume
Inspiratory capacity
Functional residual capacity
Vital capacity

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13
Q

How do you calculate functional residual capacity?

A

Expiratory reserve volume + Residual volume

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14
Q

How do you calculate vital capacity?

A

Expiratory reserve volume + Tidal volume + Inspiratory reserve volume

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15
Q

How do you calculate Inspiratory capacity?

A

Tidal volume + Inspiratory reserve volume

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16
Q

How do you calculate minute ventilation?

A

Breathing frequency * Tidal volume

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17
Q

How do you calculate alveolar ventilation(Gas entering and leaving the alveoli)?

A

(Tidal volume - Dead space) * Breathing frequency

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18
Q

What factors affect lung volumes and capacities?

A

Body size
Sex
Disease
Age
Fitness

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19
Q

def Physiological dead space

A

Anatomical + Alveolar dead space

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20
Q
A

16
150mL
Anatomical dead space

21
Q
A

No blood supply
0mL
Alveolar dead space

22
Q
A

7
alveolar ventilation

23
Q
A

Spring outwards
Recoil inwards

24
Q

What constitutes the neutral position of the chest

A

Equilibrium forces of the chest wall and the lung

25
What muscular impact causes inspiration?
25
What muscular impact causes expiration?
26
What pressure change occurs in negative pressure breathing?
27
What pressure change occurs in positive pressure breathing?
28
What is the function of the internal and external intercostal msucles?
Internal: Pull ribcage down and in External: Pull ribcage up and out
29
30
What does Daltons' law describe?
31
What does Ficks' law describe?
32
What does Henrys' law describe?
33
What does Boyles' law describe?
34
What does Charles' law describe?
35
How does air composition change per altitude?
Composition remains the same, only volume changes
36
What happens to air as it passes down the respiratory tree?
WARMED, HUMIDIFIED, SLOWED and MIXED
37
Describe the structure of Haemoglobin
Haemoglobin monomers consist of a ferrous iron ion (Fe2+; haem- ) at the centre of a tetrapyyrole porphyrin ring connected to a protein chain (-globin); covalently bonded at the proximal histamine residue
37
At what point in the respiratory tree does CO2 and H2O become present?
CO2 - Respiratory airways H2O - Conducting airways
38
How is Haemoglobin an allosteric protein?
2,3-DPG binds to allosteric site on Hb, **decreasing Hbs' affinity for O2**
39
What causes a left shift on the Hb O2 dissociation curve?
40
What causes a right shift on the Hb O2 dissociation curve?
41
What causes an upwards shift on the Hb O2 dissociation curve?
41
What causes a downwards shift on the Hb O2 dissociation curve?
42
What causes a downwards and leftwards shift on the Hb O2 dissociation curve?
43
Where would the curves for foetal Hb and myoglobin be on this graph and why?
44
What are the 3 ways CO2 is generally transported in the blood?
In solution(Plasma) Bicarbonate (HCO3-) Carbamino compounds (e.g. HbCO2)
44
What are the 3 ways CO2 is loaded into tissues and which is fastest and why?
1. CO2 stays in solution in plasma 2. CO2 binds to amine end of globin chains 3. CO2 is enzymaticaly **converted to bicarbonate and moved back to plasma(fastest due to enzyme action)**