Vasopressin Signaling at the Nephron Flashcards
1
Q
On what tissues does vasopressin act to modulate blood pressure
A
Blood vessels
Nephrons
2
Q
Synonyms for vasopressin
A
Arginine vasopressin (AVP)
Antidiuretic hormone (ADH)
3
Q
Location of action of vasopressin in the nephron
A
V2 receptors on principal cells of collecting tubules and collecting ducts
4
Q
V2 receptors are what type of G protein
A
Gs
5
Q
Intracellular action of PKA following V2 receptor activation
A
Phosphorylates aquaporin 2 channels and activates transport and fusion (exocytosis) of aquaporin- containing vesicles into the apical membrane
6
Q
Effect of increased aquaporin 2 in the apical membrane
A
Increased water reabsorption
