ANS Reflexes Flashcards
Key points of integrations between the ANS and endocrine system
Renin-angiotensin-aldosterone system (RAAS)
Vasopressin
Glucocorticoids
Insulin
Five components of the biological feedback loop (arc)
Sensor
Afferent pathway
Control center
Efferent pathway
Effector organ or tissue
Component of the biological feedback loop that monitors the environment
Sensor
Component of the biological feedback loop that detects and change in a variable
Sensor
Component of the biological feedback loop that conducts the action potential towards the control center
Afferent pathway
Most common location of control center
CNS
Component of the biological feedback loop that links the sensor and control center
Afferent pathway
Component of the biological feedback loop that modifies output to effector
Control center
Component of the biological feedback loop that maintains a set point
Control center
Component of the biological feedback loop that links the control center to the effector organ/ tissue
Efferent pathway
Pathway that is almost alway a 2- neuron pathway (pre- and post- ganglionic)
Efferent pathway
Component of the biological feedback loop that elicits a physiologic change to restor homeostasis
Effector
Effector tissues/ organs in autonomic (visceral) reflex arcs
Smooth muscle
Cardiac muscle
Glands
Fast- acting reflex loops between the cardiovascular system and CNS
Cardiovascular reflexes
Short term BP control takes place via what mechanism?
Neural (ANS reflexes–> mechanoreceptors)
Longer term BP control takes place via what mechanism
Hormonal (RAAS, vasopressin, natriuretic peptides)
List the cardiac reflexes
Baroreceptor
Bainbridge
Bezold- Jarisch
Chemoreceptor
Vasovagal
Oculocardiac
Reflex that aims at maintaining BP around a setpoint
Baroreceptor reflex
Reflex that is responsible for maintaining BP during position changes
Baroreceptor reflex
Why do patients with chronic hypertension not tolerate hypotension well?
Baroreceptors have adapted to the higher BP and increased the set point for autoregulation
Location of high-pressure baroreceptors
Transverse aortic arch
Bifurcations of the carotid arteries
Afferent pathway of baroreceptor reflex
Transverse aortic arch > Vagus n (CN 10)
Carotid bifurcation > carotid sinus n (Hering’s n) > glossopharyngeal n (CN 9)
Where is the control center for the baroreceptor reflex?
Nucleus tractus solitarius (NTS) in the medulla
The spinal cord origin of cardioaccelerator fibers
T1-T4
Effect on baroreceptor reflex: volatile anesthetics
Impair in a dose-dependent fashion
Volatile anesthetic associated with the least impairment of the baroreceptor reflex
Isoflurane (has mild B1 agonist properties)
Effect on baroreceptor reflex: Propofol
Usually impairs
Effect on baroreceptor reflex: Ketamine
Activates SNS = increased HR with minimal change in SVR
Effect on baroreceptor reflex: Etomidate
Usually unchanged HR with small decrease in SVR
Effect on baroreceptor reflex: Thiopental
Preserves reflex
Decrease SVR with compensatory increase in HR
Effect on baroreceptor reflex: hydralazine
Preserves reflex
Decrease SVR d/t vasodilation and increase HR