ANS Receptors Flashcards
Alpha 1 receptor type
Gq
Alpha 2 receptor type
Gi
Beta (1,2,3) receptor type
Gs
ACh- Nicotinic receptor type
Ion channels
Muscarinic 1,3,5 receptor type
Gq
Muscarinic 2, 4 receptor type
Gi
Dopamine 1 receptor type
Gs
Postsynaptic
Dopamine 2 receptor type
Gi
Presynaptic
Vasopressin 1 receptor type
Gq
Vasculature
Vasopressin 2 receptor type
Gs
Renal tubules
Histamine 1 receptor type
Gq
Histamine 2 receptor type
Gs
Beta-1 effects
Positive inotropy, chronotropy, and dromotropy
Beta 2 effects
Bronchodilation
Bladder sphincter contraction
Increased renin secretion
Vasodilation (skeletal muscle)
Alpha-1 effects
Vasoconstriction (GIT, skin)
Sphincter contraction (GIT, urinary tract)
Increase sweating
Decrease pancreatic activity
Increase renin secretion
Pupil dilation
M2 effects
Negative inotropic, chronotropic, and dromotropic effects
M3 effects
Bronchoconstriction
Increase pulmonary secretions
Increase GIT activity (motility, sphincter relaxation, gland secretion)
Increase salivation, lacrimation, pancreatic activity
Bladder sphincter relaxation
Pupil constriction
M1 effects
Increase salivation, lacrimation, and pancreatic activity
Arterial vasoconstriction
Alpha 1> alpha 2
Venous vasoconstriction
Alpha 2> alpha 1
Venodilation
Beta 2
Coronary vasoconstriction
Alpha 1 and 2
Coronary vasodilation
B2
DA1
Skeletal muscle vasoconstriction
Alpha 1
Skeletal muscle vasodilation
Beta 2
M3
Cerebral vasoconstriction
M1
Cerebral vasodilation
M2
M5- formation of NO
Mydriasis
Alpha 1
Miosis
M3
M2
Aqueous humor secretion
Beta-1
Decreased insulin secretion
Alpha-2
Increased insulin secretion
M3
Glycogenolysis and gluconeogenesis
Alpha 1
Beta 2
Increased renin release
Beta-1
DA-1
Diuresis
Alpha-2
Alpha-2 nervous system effects and receptor locations
Decrease SNS tone (medulla)
Increase PNS tone (vagus nerve)
Sedation, hypnosis (locus coeruleus)
Analgesia (dorsal horn of spinal cord)
Antishivering
V1 cellular receptor
Mediates cardiovascular effects such as increased SVR
V2 cellular receptor
Primarily function in the kidney as an antidiuretic hormone
V3 cellular receptor
Found in pituitary gland and modulate autocoids