VASOPLEGIA Syndrome

Question 1

1. What is and how is vasoplegia syndrome diagnosed? Understand the basic
   pathophysiology of this syndrome.

Answer 1

Severe systemic vasodilation (vasoplegia, vasodilatory shock) with markedly decreased SVR. Severe persistent post op hypotension despite normal or increased CI, low MAP
May be cause by SIRS

Question 2

2. Please know 3 medication CLASSES that have been discussed this semesternthat can lead to the development of vasoplegia syndrome.

Answer 2

• ACE inhibitors
• Heparin
• Angiotensin Receptor Blockers

Question 3

3. Please know the treatment of choice for Vasoplegia syndrome?

Answer 3

Treatment of choice is Vasopression 0.01 to 0.04 units minute
Norepinephrine OR phenyleprhine

Question 4

Alternate medication treatment options if the treatment of choice fails.

Answer 4

Methylene blue 1 -2 mg/kg IV

Norepinephrine
Phenylephrine

Question 5

Basic Patho of Vasoplegia Syndrome

Answer 5

1. Activation of contact, coagulation and complement systems
2. The activation of leukocytes, platelets and endothelial cells resulting in an IMBALANCE IN THE REGULATION OF THE VASCULAR TONE.