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SRNAPharmacology I > Inhbitors of > Flashcards

Inhbitors of Flashcards

1
Q

APROTININ (trasyrol)

A

Discontinued

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2
Q

APROTININ (trasyrol) MOA

A

Nonspecific agents acts by forming reversible stoichometry enzyme inhibitor complexes and inhibits human trypsin, plasmin, plasma and tissue kallikelein, elastase and urokinase.

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3
Q

Preserve platelet function

A

APROTININ (trasyrol)

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4
Q

The inhibition effects on the various serine protease enzymes

A

concentration dependent

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5
Q

Aprotinin action

A

inhibit plasmin at low concentration (anti-inflammatory response and antifibrinolytic )

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6
Q

A test dose of Aprotinin (IMPORTANT ) don’t need to know the dose

A

1ml should always be administered at least 10 minutes before the loading dose.

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7
Q

AMINOCAPROIC ACID is a _______Derivative of

A

synthetic derivative of amino acid lysine inhibitor of fibrinolysis

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8
Q

AMINOCAPROIC ACID effects

A

Inhibition of fibrin degradations which allows for the formation of a more stable clot

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9
Q

AMINOCAPROIC ACID pharmacokinetics

Vd?, metabolism, half life

A

High Vd
Minimal metabolism
SHORT HALF LIFE

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10
Q

Aminocaproic acid warning/contraindications

A

Clotting

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11
Q

AMINOCAPROIC ACID side effect

A

GI issues

INCREASE AspIRATION GIVEN PO

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12
Q

AMINOCAPROIC ACID can cause ______

A

Can cause DIC

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13
Q

TRANEXAMIC Acid (cyklokapron) is a

A

Synthetic derivative of amine lysine

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14
Q

TRANEXAMIC Acid (cyklokapron) MOA

A

Same a Aminocarpori acid (stop bleeding)

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15
Q 
TRANEXAMIC Acid (cyklokapron)  clearance
half life?
A 
Renal excretion (GFR)
half life 2 hours
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16
Q

Dosing rate of TRANEXAMIC acid
Do not give how?
Why?

A

Do not give faster than 100mg/min

DUE TO RISK OF HYPOTENSION

17
Q

Range of dosing Tranexamic acid

A

1-2 gs

18
Q

TRANEXAMIC acid adverse effects 1

A

Visual defects post op

Can cause permanent blindness

19
Q

TRANEXAMIC Acid (cyklokapron) adverse effects 2

A

CONVULSION seizure -greater risk with higher dosing

because GABA receptors booking

20
Q

TRANEXAMIC Acid (cyklokapron) contrainedicated in what kind of patients?

A

not be given with patients with CLOTTING

SRNAPharmacology I (29 decks)

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