SEROTONIN RECEPTORS

Question 1

There are currently _____serontonin

Answer 1

14 serotonin receptor subtypes

Question 2

All except ______are GS protein

Answer 2

5-HT 3 receptors,

Question 3

5 HT3 receptors subtype is located in both the

Answer 3

central and peripheral nervous systems

Question 4

In CNS highest concentration found in

Answer 4

Chemoreceptor ciliary Tract

Question 5

Selective 5-HT3 receptor antagonists

Answer 5

Selectively antagonize the 5-HT3 receptor subtype

Question 6

Selective 5-HT3 receptor antagonists

Answer 6

Dolansetron
Granisetron
ondansetron equally efficacious at equivalent doses

Question 7

Dolansetron
Granisetron
ondansetron

Answer 7

both available in oral and IV

Question 8

Only available in IV

Answer 8

PALONOSETRON

Question 9

MOA of 5-HT3 receptor antagnosis

Answer 9

Selectively bind and inhibit 5-HT 3 receipts blocking the binding of serotonin at this receptor subtype and subsequent N/V
Peripherally and centrally

Question 10

These agents are not effective in

Answer 10

motion induced N/V from vestibular stimulation

Question 11

UNIQUE long half life

Answer 11

PALONOSETRON (ALOXI) 40 hours

Question 12

PALONOSETRON(ALOXI)

Answer 12

Takes long ot work

Question 13

Most common side effects

Answer 13

Headache (MOST COMMON)

Dose dependent QT prolongation

Question 14

New warning for 5-HT3 receptor antagonists.

Answer 14

The development of serotonin syndrome reported with 5-HT3 receptors antagonist

Question 15

New warning for 5-HT3 receptor antagonists.

Answer 15

The development of serotonin syndrome reported with 5-HT3 receptors antagonist.
reported with repeated administration, cases were fatal

Question 16

The prototypical selective 5-HT3 receptor antagonists

Answer 16

ONdansetron 4-8mg IVP 2-4 minuts

Question 17

Ondansetron dose < or equal to 40kg

Answer 17

0.1mg/kg over 2-5 minuts for prophylaxis

Question 18

Ondansetron dose > or equal to 40kg

Answer 18

4mg IVP over 2-5 minutes for phorphylaxis

Question 19

Patients with severe hepatic impairment

Answer 19

Total dose of 8 mg

Question 20

Drug-drug interactions

Answer 20

APOMORPHINE : profound hypotension and LOC can occur and for this reason ONDANSETRON is CONTRAINDICATED with concomittant use.

Question 21

DOLASETRON metabolism

***KNOW ACTIVE METABOLITE

Answer 21

Active, not a prodrug completely metabolized by plasma carbonyl reductase enzyme to an active metabolite.
HYDRODOLASETRON

Question 22

PONV prophylaxis DOLASETRON

Answer 22

100mg PO 2 hours before surgery
12.5 mg IV 15 mins before surgery
15 min before cessation

Question 23

PONV treatment ***(compare tx vs prophylaxis)

Answer 23

12.5 mg IV as soon as NV presents

Question 24

PALONOSETRON (ALOXI)

Answer 24

good drug, last longer

DO NOT USE BECAUSE OF “cost” 200-300 a dose

Question 25

PALONOSETRON (ALOXI) not used because

Answer 25

takes forever to work

not for acute