Vasculitis part II

Question 1

Sx cyroglobulinemia

Answer 1

raynauds
cutaneous ulceration
cold induced urticaria
digital gangrene
polyarthralgias
purpura
nephritis
peripheral neuropathy

Question 2

what can cause foot drop

Answer 2

polyarteritis nodosum
cryoglobulinemia
microscopic polyangiitis

Question 3

what is mixed cryoglobulinemia assoc with

Answer 3

hep C and sjogrens

Question 4

what types of cryoglobulinemia assoc with RF activity

Answer 4

type II and III

mixed IgG IgM

Question 5

C’ level in cryglobulinemia

Answer 5

low C4

Question 6

antiglomerbular BM

Answer 6

goodpastures

Question 7

what is churg strauss

Answer 7

eosinophilic granulomatosis with polyangiitis

Question 8

C-ANCA

Answer 8

anti PR 3

wegener

Question 9

P ANCA

Answer 9

anti MPO

myeloperoxidase

Question 10

what has P ANCA

Answer 10

churg strauss

microscopic polyangiitis

Question 11

what C’ pathway do ANCA related vasculitis activate

Answer 11

alternate C’ pathway

Question 12

What ANCA vasculitis does not form granulomas

Answer 12

microscopic

Question 13

pneumonitis without nodules
L foot drop
RBC cast with hemopotysis
nongranulomatous nectrozing vasculitis of arterioles
no upper respiratory involvement

Answer 13

microscopic polyangiitis

Question 14

RBC in Ua with hemoptysis and nodules on CXR
migratory oligoarthropathy
stridor
conductive hearing loss
previous dVT

Answer 14

granulomatous polyangitis

wegeners

Question 15

What do you look for if suspect wegeners

Answer 15

C ANCA

PR-3

Question 16

Wegeners

Answer 16

nasal otic ocular or oral inflammation
abnoraml CXR
urinary sed inc
oligoarthritis, neuropathy, uveitis and DVTs

Question 17

what kills wegeners patients

Answer 17

renal failure

Question 18

signs eosinophilic granulomatosis with polyangitis

Answer 18

asthma
eos!
mono or polyneuropathy
transitory pulm infiltrates
paranasal sinus abnormalities
Bx with extravasc eos

Question 19

Iranian or turkish patient

Answer 19

behcets

Question 20

blurred bision with oral and penile pain

PMH pathergy

Answer 20

behcets

Question 21

What is cogans

Answer 21

chlamydia Ab to cornea and inner ear
interstitial keratitis and vestibuloauditory dysfunction
part of IgG4-RD

Question 22

Ab are against what in behcets

Answer 22

the heat shock proteins

Question 23

HLA behcet

Answer 23

B51

Question 24

causes behcet

Answer 24

strep sanguis

Question 25

triad behcet

Answer 25

painful apthous ulcers: mouth and genitals 3x in 1 year
pan uveitis
meningoencephalitis
arthritis
E nodosum
phlebitis
pathergy

Question 26

erysipelas like plaque

Answer 26

Familial Mediterranean Fever

Question 27

What causes FMF

Answer 27

absence pyrin so IL8 not inactivated

increasing neutrophil cytokines

Question 28

most common Sx FMF

Answer 28

abdominal pain and arthritis

Question 29

Dx of FMF

Answer 29

Bx with amyloid or scintography withs serum amyloid protein

Question 30

hot ankle rash

Answer 30

FMF

Question 31

what indicates renal amyloidosis

Answer 31

renal proteinuria

Question 32

tx FMF

Answer 32

colchicine

Question 33

what runs without stop in FMF

Answer 33

IL-1 beta and Th1 pathway

Question 34

vertebral basilar TIA
ataxia slurred speech
altered mental status
reduced L middle cerebral argery

dx

Answer 34

primary angiitis of CNS

Question 35

CD in primary angiitis CNS

Answer 35

CD4

Question 36

string of beads on vasculature cerebraum

Answer 36

primary angiitis of CNS

Question 37

what drugs can cause cutaneous leukocytoclastic vasculitis

Answer 37

Antibiotics like penicillins
phenytoin
PTU
thiazides

Question 38

clinical sign cutaneous luekocytoclastic vasculitis

Answer 38

palpable purpura

Question 39

what systemic diseases are assoc with vasculitis

Answer 39

lupus
rhematoid
sarcoid