Rheumatology and RA, Told, Part II

Question 1

What are DMARDs

Answer 1

disease modifying antirheumatic drugs: hydroxychloroquine sulfasalazine gold compounds azathioprine cyclosporine methotrexate leflunomide

Question 2

pros MTX

Answer 2

once week dosing facorable rate of continuing therapy good for mod-severe RA

Question 3

cons to MTX

Answer 3

lab monitoring for CBC and LFTs and Creatinine toxicity alopecia, hepatic, myelosuppression pulmonary

Question 4

MTX and pregnancy

Answer 4

contraindicated teratogenic

Question 5

Pros leflunomide

Answer 5

well absorbed, early onset action, can be used long term rapid excretion with cholestyramine by gallbladder

Question 6

cons of leflunomide

Answer 6

lack clinical experience hepatic GI toxicities, teratogenic super super expensive

Question 7

What is infliximab

Answer 7

chimeric monoclonal anti TNF a Ab

Question 8

what is adalimumab

Answer 8

human monoclonal anti TNF a Ab humera

Question 9

what is a soluble TNF R drug

Answer 9

etanercept

Question 10

what is kineret

Answer 10

recombinant IL 1 R antagonist

Question 11

what are the risks of biologic drugs

Answer 11

increased risk of infection, must test for TB before start therapy

Question 12

Remission criteria for RA

Answer 12

Need 5+ for 2+ months: AM stiffness<20 F

Question 13

low dose steroids are used in RA when

Answer 13

flares or switching medications

Question 14

What is this

Answer 14

degnerative joints

RA