Vasculitis part I Flashcards
What causes vasculitis
IC and actiation of C’
what do you see in vasculitis vessel
damage to walls
leukocytoclastic changes
necrosis and thrombosis
clinical Sx of vasculitis is determined how
vessel size
what are the constitutional Sx in vasculitis
fever, weight loss, malaise
what are the large vessel vasculitis clinical manifestations
limb claudication asymmetric BP absence of pulses bruits aortic dilation
clinical manifestations of medium vessel vasculitis
ulcers arthritis livedo reticularis digital gangrene Mononeuritis multiplex!! microaneurysms
clinical manifestations of small vessel vasculitis
purpura urticaria glomerulonephritis alveolar hemorrhage arthritis splinter hemorrhages uveitus episcleritis scleritis
behcets
vessel vasculitis of any size
What are the large vessel vasculitis
takayasu arteritis
giant cell arteritis
what are the medium vessel vasculitis
polyarteritis nodosa
kawasaki disease
what are the small vessel vasculitis
ANA assoc
IC associated
What are the ANCA related small vessel vasculitis
microscopic polyangiitis
granulomatosis with polyangiitis(wegener)
eosinophilic granulomatosis with polyangiitis (churg strauss)
What are the IC related small vessel vasculitis
Ant GBM
cryoglobulinemic vasculitis
IgA HSP
hypocomplemetemic urticarial vasculitis
what are the variable vessel vasculitis
behcets
cogans IgG4 related
what are the single organ vasculitis
cutaneous vasculitis
primary CNS vasculitis “string of beads”
most common presentation of vasculitis syndrome
palpable purpura
what causes inflammatroy palpable purpura
leukocytoclastic vasculitis
what is used for Tx remission vasculitis
glycocorticoids and cyclophosphamides
maintenance of vasculitis
AZA or MTX or mycophenolate
what is temporal arteritis
granulomatous giant cell arteritis
takayasu arteritis race
asian
BP different in R arm compared to L
large arter vasculitis
2 phases of takayasu arteritis
early inflammatory and late occlusive
bruit heard where in takayasu
subclavian or aorta
what is pulseless disease and Tx
takayasu arteritis
Tx steroids
jaw claudication or pain with chewing
temporal arteritis
stenosis wehre with temporal arteritis
subclavian stenosis or aneurysm
Sed rate is extremely high
temporal arteritis
fever of unknown origin
temporal arteritis
What can termporal arteritis look like
polymyalgia theumatica
main signs temporal arteritis or giant cell
>50 y.o Feve unkown origin paraneoplastic jaw claudication proximal pain and stiffness elevated ESR inc alk phos
left wrist drop and right foot drop fever arthralgias HTN hematuria testicular tenderness hep B + med size vesslaneurysms
polyarteritis nodosum
signs polyarteritis nodosum
][livedo reticularis
foot drop or polyneuropathy
Sx polyarteritis nodosum
HTN fever weight loss abdominal pain lungs spared testicular pain or tenderness myalgias
labs for polyarteritis nodosa
azotemia, anemia
Hep B virus
Bx skin nerve muscle or testicles
angiogram renal, mesenteric hepatic artery
med vessel aneurysms
polyarteritis nodosa
child with fever for 5 days
erythema and edema palms soles
cervical adenopathy
Kawasaki syndrome
concerned about what in kawasaki disease
coronary artery aneurysm
kawasaki disease criteria
needs fever >5 days
4/5 of the following:
- conjunctivitis
- rash: erythematous, maculopapular, mobiliform
-erythema palms and soles
-adenopathy, cervical
- mucous membrane dry red strawberry tongue
lab to order in kawasaki disease
echo to make sure heart is okay
SLE patient with wheals that don’t go away followed by echymosis
C’ levels low
urticarial vasculitis
what is the Anti C1q vasculitis
hypocomplemetemic urticarial vasculitis
what produce urticaria ain urticarial vasculitis
C3a and C5a
what cause urticarial vasculitis
CT diseases
hep B or C
what causes hypocomplementemic form urticarial vasculitis
SLE with Ab to Cq1 and vascular endothelial cells
18 y.o with fever palpable skin lesions arthralgias hematuria abdominal pain GI bleeding Ig involved
IgA
Sx with HSP
purpura
arthritis
GI abdominal pain with bleeding
what is the single organ IgA disease
beurgers
typical UA finding in HSP
RBC cast in urine
sat on cold bleacher and caused necrotizing vasculitis
mixed cryoglobulinemia
what to eval patient for with mixed cryoglobulinemia
hep C
