CTD part IV

Question 1

extraglandulat sjogrens

Answer 1

periepithelial kidney liver lungs
type I RTA from T cells
glomerulonephritis neuropathy adn vasculitis through cryoglobulins- B cells

Question 2

B cell attack SS

Answer 2

glomerulonephritis, neuropathy and vasculitis from cryoglobulins

Question 3

T cell attack SS

Answer 3

periepithelial effects in kidneys liver or lungs

type I RTA

Question 4

what damage do cryoglobulins do

Answer 4

small vessel vasculitis
purpura
peripheral neuropathy
glomerulonephritis

Question 5

watch fro what neoplasm in SS

Answer 5

lymphoma

Question 6

What is relapsing polychondritis

Answer 6

Ab to type II collagen

HLA DR4

Question 7

signs of relapsing polychondritis

Answer 7

episcleritis- red eyes
bilateral auricular chondritis
nasal chondritis
respiratory chondritis
tracheal stenosis

Question 8

how are IgG4 related diseases Dx

Answer 8

Bx

obliterative phlebitis

Question 9

minor criteria IgG4 RD

Answer 9

non obliterative phlebitis

mild eos infiltrate

Question 10

major criteria IgG4 RD

Answer 10

bx
lymphoplasmacytic infiltrate wthi plasma cells
sotriform fibrosis
obliterative phlebitis!!

Question 11

what is obliterative phlebitis

Answer 11

inflammation of wall of vein that it is obstructed

Question 12

large joint arthritis, fevers, night sweats, anorexia, diarrhea, weight loss
lymphadenopathy HSM and hyperpigmentation
Rf and anti CCP negative

Answer 12

Whipples

Question 13

first stgae whipples

Answer 13

prodromal, migratory arthritis

Question 14

second stage whipples

Answer 14

steady state– diarrhea and weight loss

Question 15

duodenal Bx of whipples

Answer 15

PAS + with infiltrating macrophages

Question 16

niacin deficiency can cause what

Answer 16

diarrhea, dermatitis, dementia