Vasculitis

Question 1

Which type of vasculitis is Henoch-Schoenlein purpura?

Answer 1

Small vessel

Question 2

Which type of vasculitis is eosinophilic granulomatosis with polyangiitis and what is it’s other name?

Answer 2

1. Small/medium vessel

2. Churg-Strauss syndrome

Question 3

Which type of vasculitis is microscopic polyangiitis?

Answer 3

Small vessel

Question 4

Which type of vasculitis is granulomatosis with polyangiitis and what is it’s other name?

Answer 4

1. Small vessel

2. Wegener’s syndrome

Question 5

Which type of vasculitis is polyarteritis nodosa?

Answer 5

Medium vessel

Question 6

Which type of vasculitis is Kawasaki disease?

Answer 6

Medium vessel

Question 7

Which type of vasculitis is giant cell arteritis?

Answer 7

Large vessel

Question 8

Which type of vasculitis is Takayasu’s arteritis?

Answer 8

Large vessel

Question 9

What is this a presentation of?
Purpura, joint and muscle pain, peripheral neuropathy, renal impairment, GI upset, anterior uveitis/scleritis, hypertension, systemic symptoms.

Answer 9

Vasculitis

Question 10

Which antibodies are involved in vasculitis?

Answer 10

Anti-neutrophil cytoplasmic (ANCA):

1. p-ANCA (anti-MPO) - microscopic polyangiitis and Churg-Strauss syndrome
2. c-ANCA (antiPR3) - Wegener’s syndrome

Question 11

What is tested for to confirm vasculitis?

Answer 11

1. Inflammatory markers - raised

2. Antibodies

Question 12

What is the pharmaceutical management for vasculitis?

Answer 12

1. Steroids targeted at affected area
2. Immunosuppressants - cyclophosphamide, methotrexate
3. Supportive in HSP
4. Aspirin and IV Ig in Kawasaki

Question 13

What is the pathophysiology of Henoch-Schoenlein purpura and what is the common patient group?

Answer 13

1. IgA deposits in blood vessels systemically often triggered by URTI/GI infection.
2. Children under age 10

Question 14

What is the typical condition that Churg-Strauss syndrome presents with?

Answer 14

Severe asthma in teens/adulthood

Question 15

What are the main features of microscopic polyangiitis?

Answer 15

1. Renal failure

2. Shortness of breath and haemoptysis in lungs

Question 16

What is the classic sign in Wegener’s syndrome?

Answer 16

1. Saddle shaped nose due to perforated nasal septum

2. Affects lungs, kidneys, nose, ears, and sinuses.

Question 17

Which infection is commonly associated with polyarteritis nodosa and what rash is it associated with?

Answer 17

1. Hepatitis B (can occur in Hep C/HIV)

2. Livedo reticularis

Question 18

Which age group is affected by Kawasaki disease and what are the clinical features?

Answer 18

1. Children under age 5

2. High fever, erythematous rash, bilateral conjunctivitis, erythema and desquamation of skin, strawberry tongue.

Question 19

Which vessels are mainly affected in Takayasu’s arteritis?

Answer 19

Aorta and its branches, can affect pulmonary arteries.