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Rheumatology and MSK > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

rx ANCA vasculitis

A

2 doses of rituximab

also steroids and azathioprine

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2
Q

how to treat pulmonary haemorrhage in vasculitis

A 
plasma exchange (removes immunoglobulins that are attacking the blood vessels)
steroids
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3
Q

causes of small vessel vasculitis

A 
HSP
wegener's (granulomatosis with polyangiitis, GPA)
eosinophilic GPA (churg strauss)
microscopic polyangiitis
SLE
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4
Q

causes of medium vessel vasculitis

A 
polyarteritis nodosa (PAN)
kawasaki
GCA
RA
SLE
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5
Q

causes of large vessel vasculitis (aorta, temporal artery)

A

kawasaki
RA
GCA
takayasu’s arteritis

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6
Q

rx

A

STEROIDS

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7
Q

what classification system is used

A

Chapel Hill (classifies based on sx and size of vessel affected)

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8
Q

what vasculitides are ANCA positve

A

some small ones
wegener’s
microscopic polyangitis
churg-strauss

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9
Q

life threatening feature of vasculitis? what ones?

A 
pulmonary haemorrhage
small vessel (e.g. wegener's and churg-strauss)
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10
Q

how to treat pulmonary haemorrhage due to vasculitis

A

steroids!

plasma exchange! (like dialysis just for the plasma - removes immunoglobulins that are attacking the blood vessels)

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11
Q

why is vasculitis related to nephrology

A

many pts end up with ESKD and are on dialysis

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12
Q

systemic and joint sx of vasculitis

A

Systemic: fever, weight loss, fatigue, aching
Joints: range from bad arthritis to aching joints

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13
Q

how do vasculitides cause injury

A

haemorrhage
ischaemia
thrombosis

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14
Q

classic rash in vasculitis

A 
"palpable purpura"
purpuric
raised
non-blanching?
usually on legs
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15
Q

pulmonary and renal sx of vasculitis

A

Resp: cough (particularly haemoptyisis), SOB -> pulmonary haemorrhage!! (scary)
Kidneys: AKI, haematuria, proteinuria

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16
Q

neuro sx vasculitis

A

headache, stroke, shooting arm and leg pain, numbness, weakness

17
Q

nose and ear sx vasculitis

A

Nose and ears: congestion, hearing loss, inflammation of the nasal septum, sometimes resulting in a perforation or collapse of the bridge of the nose, as shown in the picture below

18
Q

sign in PAN (polyarteritis nodosa)

A

small aneuerysms strung like beads of a rosary “rosary sign”

19
Q

PAN associated with what infecftions

A

hep b and c

20
Q

most common symptoms in behcet’s disease

A

CLASSIC TRIAD
v v painful mouth and genital ulcers. RECURRENT
uveitis
arthritis

sometimes also have skin lesions incl erythema nodosum
(NB is a multisystem disease)

21
Q

behcet’s commonly seen in

A

men of turkish origin

22
Q

what is the pathergy test in behcet’s

A

minro skin trauma induces inflammatory pustule after 24-48 hrs

23
Q

rx behce’ts

A

topical steroids

may require systemic rx

Rheumatology and MSK (21 decks)

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