Vasculitis Flashcards

1
Q

most widely accepted pathogenic mechanism

A

immune complex deposition

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2
Q

cANCA staining

A

diffuse granular cytoplasmic staining

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3
Q

pANCA staining

A

localized perinuclear or nuclear staining pattern

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4
Q

Major ANCA antigen cANCA

A

proteinase 3

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5
Q

Major ANCA antigen pANCA

A

myeloperoxidase

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6
Q

Granulomatous vasculitis of the upper and lower respiratory tracts + glomerulonephritis

Hallmark: necrotizing vasculitis of small arteries and veins

A

Wegener’s (Granulomatosis with polyangitis)

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7
Q

Typical lung pathology in Wegener’s

A

nodular cavitary infiltrates

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8
Q

Small vessel vasculitis

A

Wegener’s

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9
Q

Kidneys, upper 95% and lower respiratory symptoms
chronic sinusitis
kidney: pauci immune GN
c ANCA + 90%
biopsy:
SADDLE NOSE deformity
necrotizing granulomatous vasculitis: lung
cyclophosphamide complete remission in 75%
+ GC

A

WEGENER’S

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10
Q

Chronic nasal passage of _____ increases replace rate of Wegener’s

A

Staph aureus

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11
Q
medium vessel vasculitis 
no lung involvement but involves bronchial vessels
NO GRANULOMA
mononeuropathy foot drop
kidneys: ARTERITIS WITHOUT GN
GI tract: aneurysms
Hep B 
p ANCA+ 
hAIRY CELL leukemia
Biopsy nerves
A

PAN -

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