Vasculitis Flashcards
most widely accepted pathogenic mechanism
immune complex deposition
cANCA staining
diffuse granular cytoplasmic staining
pANCA staining
localized perinuclear or nuclear staining pattern
Major ANCA antigen cANCA
proteinase 3
Major ANCA antigen pANCA
myeloperoxidase
Granulomatous vasculitis of the upper and lower respiratory tracts + glomerulonephritis
Hallmark: necrotizing vasculitis of small arteries and veins
Wegener’s (Granulomatosis with polyangitis)
Typical lung pathology in Wegener’s
nodular cavitary infiltrates
Small vessel vasculitis
Wegener’s
Kidneys, upper 95% and lower respiratory symptoms
chronic sinusitis
kidney: pauci immune GN
c ANCA + 90%
biopsy:
SADDLE NOSE deformity
necrotizing granulomatous vasculitis: lung
cyclophosphamide complete remission in 75%
+ GC
WEGENER’S
Chronic nasal passage of _____ increases replace rate of Wegener’s
Staph aureus
medium vessel vasculitis no lung involvement but involves bronchial vessels NO GRANULOMA mononeuropathy foot drop kidneys: ARTERITIS WITHOUT GN GI tract: aneurysms Hep B p ANCA+ hAIRY CELL leukemia Biopsy nerves
PAN -