Vasculitis

Question 1

Most common cause of vasculitis:

Answer 1

-Secondary disease

Question 2

Four Process of Vasculitis:

Answer 2

1. ) Immune Complex Deposition
2. ) Autoimmune Anti-Neutrophil Antibodies
3. ) Pathogen T cell response with granuloma formation
4. ) Combination of 2 and 3

Question 3

Autoimmune anti-neutrophil antibody theory:

Answer 3

• Neutrophils become targets
• Antibodies kill neutrophils
• Neutrophils die releasing oxidases
• Endothelial cell damaged
• Anti-endothelial antibodies created

Question 4

Cellular immune response:

Answer 4

-Interferon gamma producing CD4+ Th1 cells -> granuloma formation

Question 5

Large Vessel Symptoms:

Answer 5

• Constitutional
• Pulselessness
• Limb Claudication
• Bruits

Question 6

Medium Vessel Symptoms:

Answer 6

• Constitutional
• Necrotic toes and fingers
• Palpable purpura

Question 7

Small Vessel Symptoms:

Answer 7

• Constitutional
• Distal changes
• Splinter hemorrhages
• Conjunctiva or retina
• Petechia
• Glomerulonephritis -> Renal Failure

Question 8

Large Vessel Vasculitis:

Answer 8

• Giant Cell

- Takayasu

Question 9

Medium Vessel Vasculitis:

Answer 9

• Polyarteritis Nodosa

- Kawasaki’s disease