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ORD Exam 2 > Dermatologic Manifestations of Systemic Diseases > Flashcards

Dermatologic Manifestations of Systemic Diseases Flashcards

1
Q

Diabetic Manifestations:

A
  • Diabetic Dermopathy
  • Acanthosis Nigricans
  • Necrobiosis Lipoidica Diabeticorum
  • Bullous Dibeticorum
  • Diabetic Ulcer
  • Skin Tags
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2
Q

Diabetic Dermopathy:

A
  • Most Common Skin finding in patients with diabetes
  • Positive correlation with number of diabetic microangiopathic complications
  • Macule, papule, patch, plaques on lower anterior legs
  • Looks like bruises on shins
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3
Q

Acanthosis Nigricans:

A
  • Hyperpigmented velvety plaques
  • Treating DM will make them RESOLVE
  • Areas where the skin folds
  • Many other associations not just DM
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4
Q

Necorbiosis Lipoidica Diabeticorum:

A
  • Collagen degradation with granuloma formation and fat deposition
  • Type 1 DM more prominent
  • Red shiny asymptomatic patches on shins
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5
Q

Bullous diabeticorum:

A
  • Painless, rapid spontaneous development
  • Not common
  • Absence of trauma appear overnight
  • Negative immunofluorescent
  • Blistering on acral areas
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6
Q

Diabetic ulcers:

A
  • Neurogenic/neuropathic ulcer
  • Often feet
  • Difficult to treat and may cause loss of function and limb loss
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7
Q

Skin Tags:

A

-Associated with Acanthosis Nigricans

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8
Q

Xanthoma Manifestations:

A
  • Eruptive
  • Tuberous/Tuberoeruptive
  • Tendinous
  • Plane
  • Xanthelasma
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9
Q

What is a xanthoma in general:

A
  • Due to intracellular and dermal lipid deposition

- Lipid disorder or paraproteinemia

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10
Q

Eruptive Xanthoma:

A
  • Red-yellow papules
  • Extremities hands buttocks
  • KOEBNER Phenomenon
  • Hypertriglyceridemia
  • Treating TGs will cause them to go away
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11
Q

Tuberous/Tuberoeruptive Xanthoma:

A
  • Yellow nodules on EXTENSOR surfaces -> ELBOW And KNEES

- High Cholesterol States

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12
Q

Tendinous Xanthomas:

A
  • Nodular lipid deposition affecting Achilles, Extensors of hand knees or elbows
  • Always clue to underlying lipid metabolism
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13
Q

Plane Xanthoma:

A
  • Yellow to orange macule papule patch plaque

- Site is a clue to the underlying disease

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14
Q

Xanthelasma:

A
  • Papable xanthomas of the eyelids

- Hyperlipidemia

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15
Q

Renal Manifestations:

A
  • Perforating Disorders
  • Calciphylaxis
  • Nephrogenic Fibrosing Dermopathy
  • Pruritis
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16
Q

Acquired Perforating Disorders:

A
  • Perforating Folliculitis: dermal material eliminated through follicles
  • Elastosis perforans serpiginosa: Transepidermal elimination of elastic fibers
  • Reactive perforating collagenosis: transepithelial elimination of altered collagen (Lesions regress)
  • Kyrle’s disease
17
Q

Elastosis perforans Serpiginosa:

A
  • Associated with Down syndrome
  • Cryotherapy helps
  • May be due to D-penicillamine
18
Q

Kyrle’s Disease:

A
  • Keratin predominantly extruded but elastic fibers and collagen may be present
  • Always on lower extremity
19
Q

Calciphylaxis:

A
  • Depoisition of calcium salts in skin due to dysregulation of calcium metabolism
  • Most severe form of metastatic calcification
  • Associated with chronic renal failure, hemodialysis, secondary hyperparathyroidism
  • Violaceous painful patches with necrosis and ulcers
  • High mortality rate
20
Q

Nephrogenic fibrosing dermopathy:

A

-Due to exposure to Gadolinium-containing contrast agent used with MRI in patients with advanced renal disease
Skin thickened and hard leading to dismobility

21
Q

Pulmonary Causes:

A

-Sarcoidosis

22
Q

Sarcoidosis:

A
  • 25% pts have skin manifestations
  • Asymptomatic red brown dermal papules and or plaques
  • Neck face upper extremities and upper trunk
  • Enlarged Lacrimal Glands
  • Atrophy in lesion
  • Yellow brown apple jelly color with diascopy
  • Elevated ACE level
  • Erythema Nodosum: sometimes in sarcoidosis; tender bruise like nodules on lower extremity -> Bruise on skin
23
Q

Rheumatologic Manifestations:

A
  • Pyoderma gangrenosum

- Reiter’s syndrome

24
Q

Pyoderma Gangrenosum:

A
  • Inflammatory, NONINFECTIOUS, ulcerative neutrophilic skin disease
  • Pustules turn to ulcers and become necrotic
  • Ulcerative colitis and Crohn Association
  • Pathergy: DAMAGE/SURGERY MAKES IT WORSE DO NOT DO SURGERY
25
Q

Reactive Arthritis:

A
  • SA after a GI GU infection
  • Chlamdia trachomatis major cause
  • Arthritis, Enthesitis, Dactylitis Back pain
  • Sausage fingers
  • Keratoderma blennorrhagica, Oral Ulcers, Anterior Uveitis
  • NSAIDs

ORD Exam 2 (11 decks)

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