Vasculitides

Question 1

3 vasculitides in lungs

associated w/ which antibodies?

Answer 1

microscopic polyangiitis (MPA), granulomatosis w/ polyangiitis (GPA), eosinophilic GPA (eGPA)

ANCA associated

Question 2

ANCA subtypes

Answer 2

PR3 (usually GPA) and MPO (usually MPA)

these are antibodies present, while GPA and MPA are disease processes

Question 3

contrast basic path of MPA, GPA, eGPA

Answer 3

MPA- no granulmas or asthma

GPA- granulomas but no asthma

eGPA- granulomas, asthma, eosinophilia

Question 4

clinical tendency of GPA

Answer 4

upper airway involvement

Question 5

clinical tendency of eGPA

Answer 5

vasculitis w/ asthma and eos

Question 6

clinical tendency of MPA

Answer 6

pathology but no granulomas, ANCA+ or pulm fibrosis

Question 7

DDx for ANCA+ lab

Answer 7

GPA, MPA, then eGPA

Question 8

DDx for anti GBM antibodies

Answer 8

goodpastures

Question 9

define pulm renal syndrome

Answer 9

renal failure w/ resp failure

glomerulonephritis and diffuse alveolar hemorrhage secondary to autoimmune

Question 10

6 possible radiological findings w/ small vasculitides

Answer 10

nodules, masses/consolidation, alveolar infiltrates, effusions, cavities, tracheal thickening

Question 11

tx for vasculitides

Answer 11

immunosuppressants- like steroids or cyclophosphamide