ILD Pathology Flashcards
define sarcoidosis
multi system non caseating granulomatous disease
epi for sarcoid
more black than white, female than male
main sx of sarcoid
SOB
radiology of sarcoid
interstitial infiltrates in bronchovascular distribution, hilar adenopathy
patho of sarcoid
tight, non caseating granulomas w/ giant cells, histiocytes
focal accumulation of epithelioid histiocytes
clinical correlates of hypersensitiviy pneumonitiis
from organic dusts, occupational or environmental exposure
acute and chronic- dyspnea, cough, fatigue
radiology of HP
bilateral interstitial or nodular pattern
patho of HP
patchy interstitial expansion, peri bronchiolar and interstitial chronic inflammation (lymphs) and loose granuloma
exposures that lead to microorganisms causing HP
hay, sugarcane, maple bark, hot tubs, ac units
animal proteins causing HP
birds, pets, grain weevils
synthetic causes of HP
organic chemicals in plastic/rubber manufacturing
pneumoconiosis clinical
inorganic dust from exposure
contrast the patho of two types of PCs
fibrogenic (silica, asbestos) cause active fibrin deposition
inert (coal) simply deposit in interstitium
radiology of silicosis
bilateral silicotic nodules in upper compartments
patho in early vs late silicosis
early: active histiocytes and fibroblasts
late: large, hyalinized, acellular fibrotic nodules
patho of asbestosis- 2 finidings
patchy sub pleural fibrosis (hyaline pink),
ferruginous bodies- asbestos fiber coated w/ rust and eaten by macrophages
patho of coal workers pneumonconiosis
main finding is coal dust macules (black masses in interstitium)
some destruction of parenchyma, mainly a space occupying lesion
clinical correlate to UIP patho pattern
Dx is IPF- poor response to steroids and high mortality
radiology of IPF
patchy subpleural infiltrates
what else can cause same radiology pattern as IPF
asbestos, rheumatic disease
patho of UIP/IPF
has BOTH temporal (old and new fibrosis) and spatial (pathologic and healthy) heterogeneity
patchy fibroblastic and fibrotic foci, alternating w/ normal parenchyma
unique gross and histological change in UIP
honeycomb change- large holes around fibrosis in the sub pleural region
