Lung Cancer patho

Question 1

main mesenchymal benign neoplasm

Answer 1

hamartoma

Question 2

main epithelial benign neoplasm

Answer 2

squamous papillomatosis

Question 3

what type of tumor is pleomorphic adenoma

Answer 3

epithelial, like salivary glands

Question 4

epi hamartoma

Answer 4

adolescence and adulthood, no newborns

Question 5

gross patho of hamartoma

Answer 5

solitary, lobulated, cartilagenous

Question 6

micro patho of hamartoma

Answer 6

normal mature mesenchymal tissue in excess/disarray- chaotic cartilage

Question 7

radiology of pulm hamartoma

Answer 7

solidary nodule, can have popcorn calcification

tends to be peripheral

Question 8

main cause of squamous cell

Answer 8

smoking!

Question 9

secretion of squamous cell

Answer 9

PTH like hormone, causes hypercalcemia

Question 10

location of squamous cell

Answer 10

bronchi, then larynx,then trachea

Question 11

patho of sqamous cell

Answer 11

can have desmosomes (intercellular bridges) and /or keratin (pearls)

Question 12

radiology of sqamous cell

Answer 12

more central than peripheral, can be spiculated or cavitating

Question 13

gross patho of sqamous

Answer 13

central spiculated or fungated mass w/i bronchus

could also be cavitating

Question 14

radiology of adeno

Answer 14

more peripheral than central nodules

ground glass opactiy

can be bilateral, esp mucinous

Question 15

differentiate adeno in situ (ACIS) and invasive adeno by size

Answer 15

ACIS- less than 3 cm, all lepidic

invasive- over 3cm lepidic or over 0.5 cm invasive

Question 16

describe some possiblities of ACIS morphology

Answer 16

lepidic growth

mucinous or non

unifocal or multi

Question 17

what marks the transition of ACIS to invasive adeno

Answer 17

crossing the basement membrane, large interstital infiltration and widening

Question 18

how can large cell carcinoma be distinguished

Answer 18

cDNA microarrays

Question 19

some definite good and bad NSCLC prognostics

Answer 19

stage, performance status, weight loss

NOT age, histology

Question 20

describe the patho cells of small cell

Answer 20

malignant neuroendocrine

no nucleoli (seen in NSCLC), high mitotic activity and necrosis, nuclear molding

also lots of pink necrosis

Question 21

describe growth pattern of mesothelioma

Answer 21

malignant, deeply invasive

epithelial, spindle, or biphasic

Question 22

radiology of mesothelioma

Answer 22

diffuse plerual involement, maybe effusion w/ loss of CP angle

thickened pleura

Question 23

what to think w/ multiple nodules

Answer 23

mets! ACIS also possible

mets is most common malignancy of lung