Vascular Histology Flashcards
What 3 tunics are arteries and veins composed of?
From inner to outer
- Tunica intima
- Tunica media
- Tunica adventitia
What are the sub layers of the Tunica intima?
- Endothelium
- Basal lamina of endothelial cells
- Subendothelium layer w/ internal elastic membrane
How is the endothelium of the Tunica intima?
Single layer of squamous epithelial cells
What is contained in the Basal lamina of the Tunica Intima ?
Thin EC layer w/ collagen, proteoglycans, glycoproteins
What is the subendothelial layer of the Tunica Intima made up of?
It’s internal elastic membrane?
Loose CT
IEM: sheet like layer of fenestrated elastic material 2/ artieres and Arterioles
What is seen in the TUnica media?
Difference in veins?
‣ Circumferentially arranged layers of SM. M.
‣ Relatively thick in arteries
-has external elastic membrane
What is the external elastic membrane of the Tunica Media?
Layer of elastin that separates the tunica media and adventitia
How is the Tunica adventitia composed?
How is it different in As. vs. Veins?
‣ Longitudinally arranged collagenous tissue w/ few elastic fibers
‣ Will merge w/ loos CT surrounding vessels
‣ Ranges from relatively thin (arterial system) to quite thick (venules/veins)
What two things can we see in the tunic adventitia?
- Vaso vasorum
2. Nervi vasorum
What is the vaso vasorum?
• Vessels of the tunica adventitia that supply blood to the vascular tunics themselves
◦ Found in large arteries and veins
What is the Nervi vasorum?
ANS input that controls contraction of vasc. Sm.
What are the characteristics of LARGE (elastic) As.?
◦ Largest vessles of the arterial system
◦ Elastin forms concentric sheets/lamellar b/w muscle cell layers
◦ NO fibroblasts!
What are the characteristics of MEDIUM (muscular) arteries?
◦ More SM - less elastin
◦ Prominent internal elastic membrane - big black ring around center
◦ Recognizable external elastic membrane
◦ Thick tunica adventitia - ~same thickness as tunica media
What are the characteristics of Small arteries and Arterioles?
Different # of Sm. M. Layers in tunica media
◦ Small arteries ‣ 8 layers of Sm M. ‣ Will also have internal elastic membrane ◦ arterioles ‣ 1-2 layers of Sm. M.
What 2 cells are present in capillaries?
- Pericytes
2. Endothelial cells
What are pericytes?
What are they controlled by?
What do they promote?
perivascular contractile cells w/ branching cytoplasmic processes
- Enclosed w/ basal lamina continuous w/ that of the endothelium
- Controlled by NO (endothelial cells)
- Promote stability of capillaries and postcapillary venules
How are endothelial cells connected in capillaries?
Function?
Via cell-cell junction (# of junctions will alter permeability)
Support the Bm and produce collagen
Involved in blood coagulation & thrombosis, local vasodilation/constriction
What are the 2 subclassifications of venules?
- Postcapillary
2. Muscular