Vascular disorders

Question 1

pathophysiology of peripheral artery disease

Answer 1

atherosclerosis leading cause of PAD

atherosclerosis - gradual thickening of the intimate (innermost layer of arterial wall and the media, middle layer)
- results from cholesterol and lipids
- progressive narrowing of artery lumen
- inflammation and endothelial injury play a major role

Question 2

what are clinical symptoms of PAD?

Answer 2

clinical symptoms occur when vessels are 60-75% blocked
- often most symptoms occur in aortoiliac system or peripheral system in lower extremities

Question 3

risk factors for PAD

Answer 3

• tobacco use
  -diabetes
  -uncontrolled hypertension
  -hyperlipidemia