Vascular Dementia/ Dementia with Lewy Bodies

Question 1

What percentage of stroke survivors are affected by post-stroke dementia or cognitive impairment ?

Answer 1

One third

Question 2

Where does Lewy body and Lewy neurite pathology most often begin ?

Answer 2

In the enteric and autonomic nervous system before ascending through the brainstem, substancia nigra, limbic system and the cerebral cortex

Question 3

Some characteristics of DLB syndrome include…?

Answer 3

Visual hallucinations, parkinsonism, fluctuating alerrtness, neuroleptic sensitivity,REM sleep behavior disorder, and often hyposmia and excessive daytime sleepiness

Question 4

Two tests than can help in distiguinshing LBD from AD ?

Answer 4

MIBG Cardiac Scintigraphy Scan illustrating cardiac postganglionic sympathetic denervation and dopamine transporter imaging using SPECT or PET

Question 5

What is present in many patients with DLB ?

Answer 5

A profound cholinergic deficit due to basal forebrain and pedunculopontine nucleus involvement (may be a factor responsible for the fluctuations, inanttention and visual hallucinations.