GBS and other Immune-Mediated Neuropathies

Question 1

Some features of Miller-Fisher Syndrome ?

Answer 1

Ataxia, Opthalmoplegia and Areflexia of limbs without weakness. It accounts for 5% of all cases and is associated with antibodies to the ganglioside GQ1b

Question 2

How high is the mortality rate of GBS ?

Answer 2

<5% , death usually results from secondary pulmonary complications.

Question 3

Which conditions are reasonable to exclude in all patients with presumptive CIDP ?

Answer 3

Vasculitis, Collagen vascular disease (especially SLE), chronic hepatitis, HIV infection, amyloidosis, DM, IBD and lymphoma.

Question 4

Two interesting differences between CIDP and GBS ?

Answer 4

CIPDP responds to glucocorticoids, whereas GBS does not. As many as 25% of patients with clinical features of CIDP also have an MGUS.

Question 5

Two features of Multifical Motor Neuropathy (MMN) ?

Answer 5

The arms are affected more frequently than the legs, and >75% of all patients are male.

Question 6

Some features of Anti-Hu Paraneoplastic Neuropathy ?

Answer 6

Marked sensory ataxia, pseudoathetosis, and inability to walk, stand, or even sit unsupported.