Myasthenia Gravis and Other Diseases of the NMJ

Question 1

Thymus abnormalities in patients with MG ?

Answer 1

In appr. 65% of patients the thymus is hyperplastic but not necessarily enlarged. An additional 10% of patients have thymic tumors (thymomas).

Question 2

Peak incidences of MG ?

Answer 2

In women in their twenties and thirties and in men in their fifities and sixties.

Question 3

Which type of weakness is especially promiment in MuSK antibody-positive MG ?

Answer 3

Bulbar weakness.

Question 4

Some differences between LEMS and MG ?

Answer 4

Patients with LEMS have depressed or absent reflexes and experience autonomic changes such as dry mouth and impotence.

Question 5

Which tests should be routinely carried out in patients with suspected MG ?

Answer 5

Thyroid function tests.