Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

General Pathology > Vascular > Flashcards

Vascular Flashcards

0
Q

Molecule secreted from damaged endothelium that induces vasoconstriction

A

Endothelin-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

4 mechanisms of edema

A

Increases vasc permeability
Increases hydrostatic pressure
Decreases oncontic pressure
Decreases lymphatic drainage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Anticoagulation factors secreted by endothelium

A

Prostacyclin (PGI2)
Nitric Oxide
Tissue Plasminogen Activator (tPA)
Thrombomodulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Procoagulant factors secreted by endothelium

A

Tissue Factor
Platelet activating factor (PAF)
Von Willebrand factor
Plasminogen Activating Inhibitor-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Major stimulus for thrombopoiesis

A

Thrombopoietin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Platelet receptor for von Willebrand factor

A

GPIb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Platelet surface receptor for fibrinogen

A

GPIIb/IIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which platelet granule contains ADP

A

Dense granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the major effect of ADP on platelets?

A

Mobilizes intracellular calcium stores

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the major anticoagulation molecules?

A

Protein C
Protein S
Antithrombin III
Tissue factor pathway inhibitor (TFPI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Activation of which clotting factors amplifies thrombin production?

A

FV

FVIII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Pro-inflammatory stimuli induce expression of which pro-coag molecule on endothelium?

A

Tissue Factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which coag factor is an important acute phase protein?

A

FVIII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Activation of which molecule initiates pathway to DIC

A

Tissue factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Gene affected in Chediak-Higashi syndrome

A

CHS-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What do platelet a-Granules contain?

A

P-Selectin
Clotting: fibrinogen, FV, vWF, Protease Nexin 2
Healing: finronectin, platelet factor 4, PDGF, TGF-B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do platelet dense granules contain?

A 
ADP
ATP
Calcium
Serotonin
Epinephrine 
Histamine
17
Q

What triggers platelet activation?

A

Thrombin
ADP
PAF

18
Q

Which clotting factor deficiencies cause moderate to severe bleeding?

A 
V
VII
VIII
IX
X
19
Q

What enhances plasminogen activation?

A

Tissue plasminogen activators (tPA)

20
Q

What is the major plasmin inhibitor?

A

a-2 antiplasmin

21
Q

Heparin-like molecules activate which molecule and effect

A

ATIII
Inactivates thrombin and FX
Potent inhibitor of coagulation

22
Q

Deficiencies of which factor cause a pro-coagulation state

A

XII

Syn. Hageman Factor

23
Q

Which Cytokine is responsible for most features of septic shock?

A

TNF

24
Q

Which factors are inhibited by ATIII?

A

IX
X
XI
XII

25
Q

Which factors are in activated by protein C

A

V

VIII

26
Q

What factor does Protease Nexin 2 inhibit?

A

XI

27
Q

Pro vs. Anti Coagulation?

Thrombospondin

A

Pro

28
Q

Pro vs. Anti Coagulation?

Platelet Factor 4

A

Pro

29
Q

Pro vs. Anti Coagulation?

Protease Nexin 2

A

Anti

30
Q

Annexin V

A

Displaces coag. Factors bound to membranes

Anti-Coag

31
Q

a1- antitryspin inhibits which factor?

A

XI

32
Q

Major Protein C inhibitor

A

a2-Macroglobulin

33
Q

Which is the Christmas Factor?

A

IX

34
Q

Which is the Laki-Lorland Factor and its function

A

XIII

Fibrin cross linking

35
Q

Which factor is also called Proaccelerin?

A

V

36
Q

Hemophilia A

A

VIII

37
Q

Hemophilia B

A

IX

38
Q

Pro-thrombin time

A

Intrinsic pathway

39
Q

Activated partial thromboplastin time

A

Extrinsic / Tissue factor pathway

40
Q

Which factor is not degraded by ATIII?

A

VII

41
Q

AQP-4 is mainly expressed on which cell?

A

Astrocytes

General Pathology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions