Vascular

Question 0

Molecule secreted from damaged endothelium that induces vasoconstriction

Answer 0

Endothelin-1

Question 1

4 mechanisms of edema

Answer 1

Increases vasc permeability
Increases hydrostatic pressure
Decreases oncontic pressure
Decreases lymphatic drainage

Question 2

Anticoagulation factors secreted by endothelium

Answer 2

Prostacyclin (PGI2)
Nitric Oxide
Tissue Plasminogen Activator (tPA)
Thrombomodulin

Question 3

Procoagulant factors secreted by endothelium

Answer 3

Tissue Factor
Platelet activating factor (PAF)
Von Willebrand factor
Plasminogen Activating Inhibitor-1

Question 4

Major stimulus for thrombopoiesis

Answer 4

Thrombopoietin

Question 5

Platelet receptor for von Willebrand factor

Answer 5

GPIb

Question 6

Platelet surface receptor for fibrinogen

Answer 6

GPIIb/IIIa

Question 7

Which platelet granule contains ADP

Answer 7

Dense granules

Question 8

What is the major effect of ADP on platelets?

Answer 8

Mobilizes intracellular calcium stores

Question 9

What are the major anticoagulation molecules?

Answer 9

Protein C
Protein S
Antithrombin III
Tissue factor pathway inhibitor (TFPI)

Question 10

Activation of which clotting factors amplifies thrombin production?

Answer 10

FV

FVIII

Question 11

Pro-inflammatory stimuli induce expression of which pro-coag molecule on endothelium?

Answer 11

Tissue Factor

Question 12

Which coag factor is an important acute phase protein?

Answer 12

FVIII

Question 13

Activation of which molecule initiates pathway to DIC

Answer 13

Tissue factor

Question 14

Gene affected in Chediak-Higashi syndrome

Answer 14

CHS-1

Question 15

What do platelet a-Granules contain?

Answer 15

P-Selectin
Clotting: fibrinogen, FV, vWF, Protease Nexin 2
Healing: finronectin, platelet factor 4, PDGF, TGF-B

Question 16

What do platelet dense granules contain?

Answer 16

ADP
ATP
Calcium
Serotonin
Epinephrine 
Histamine

Question 17

What triggers platelet activation?

Answer 17

Thrombin
ADP
PAF

Question 18

Which clotting factor deficiencies cause moderate to severe bleeding?

Answer 18

V
VII
VIII
IX
X

Question 19

What enhances plasminogen activation?

Answer 19

Tissue plasminogen activators (tPA)

Question 20

What is the major plasmin inhibitor?

Answer 20

a-2 antiplasmin

Question 21

Heparin-like molecules activate which molecule and effect

Answer 21

ATIII
Inactivates thrombin and FX
Potent inhibitor of coagulation

Question 22

Deficiencies of which factor cause a pro-coagulation state

Answer 22

XII

Syn. Hageman Factor

Question 23

Which Cytokine is responsible for most features of septic shock?

Answer 23

TNF

Question 24

Which factors are inhibited by ATIII?

Answer 24

IX X XI XII

Question 25

Which factors are in activated by protein C

Answer 25

V | VIII

Question 26

What factor does Protease Nexin 2 inhibit?

Answer 26

XI

Question 27

Pro vs. Anti Coagulation? | Thrombospondin

Answer 27

Pro

Question 28

Pro vs. Anti Coagulation? | Platelet Factor 4

Answer 28

Pro

Question 29

Pro vs. Anti Coagulation? | Protease Nexin 2

Answer 29

Anti

Question 30

Annexin V

Answer 30

Displaces coag. Factors bound to membranes | Anti-Coag

Question 31

a1- antitryspin inhibits which factor?

Answer 31

XI

Question 32

Major Protein C inhibitor

Answer 32

a2-Macroglobulin

Question 33

Which is the Christmas Factor?

Answer 33

IX

Question 34

Which is the Laki-Lorland Factor and its function

Answer 34

XIII | Fibrin cross linking

Question 35

Which factor is also called Proaccelerin?

Answer 35

V

Question 36

Hemophilia A

Answer 36

VIII

Question 37

Hemophilia B

Answer 37

IX

Question 38

Pro-thrombin time

Answer 38

Intrinsic pathway

Question 39

Activated partial thromboplastin time

Answer 39

Extrinsic / Tissue factor pathway

Question 40

Which factor is not degraded by ATIII?

Answer 40

VII

Question 41

AQP-4 is mainly expressed on which cell?

Answer 41

Astrocytes