Immunity Flashcards
What are the three types of RLRs?
RIG-1
MDA-5
LPG-2
PRRs in cytosol
TLRs
RLR (Rig-1 like receptors)
NLRs (NOD-like receptors)
What is the universal signaling molecule for NFkB?
MyD88
Which molecule is associated with the TCR?
CD3
Which is the co-stimulated molecule on T cells?
CD28
What molecule on the APC binds to the co-stimulator molecule on the T cell?
CD80 (syn. B7-1)
CD81 (syn. B7-2)
In which species is the gamma-delta T-cell the most common type?
Ruminants and pigs
Double negative (CD4-/CD8-) T cells are rare in all species except ______.
Pigs and cattle
Double positive (CD4+/CD8+) T cells are rare in all species except ______.
Pigs
Which cytokines are secreted by TH1 cells?
IL-2
IFN-gamma
TGF-B
Which cytokines are secreted by TH2 cells?
IL-4
IL-5
IL-13
What is the key marker of T Reg cells?
CD25
Activated macrophages produce which cytokine to stimulate a TH1 response?
IL-12
Cytokines produced by T Reg cells
IL-4
IL-10
TGF-B
Transcription signalling molecule for TH1 T cells
T-bet
Transcription signalling molecule for TH2 T cells
GATA-3
Transcription signalling molecule for T-reg cells
FoxP3
Which cytokines stimulate TH 17 cells?
IL-23
Cytokines produced by TH 17 cells
IL-17
IL-22
Most important stimulator of macrophages and dendritic cell development?
Colony Stimulating Factor-1
Cell types that express MHC II?
B cells
Macrophages
Dendritic Cells
Molecule secreted by TH1 cells that is a potent macrophage activator.
IFN-gamma
Cytolytic molecules in natural killer cell granules
Perforin
Granzyme
Surface markers for NK Cells
CD16
CD56
Cytokine produced by NK cells & result
IFN-gamma -> TH1 bias
Cytokine subfamily produced by activated T cells
C-C
Cytokine subfamily produced by activated macrophages and endothelium
CXC
Cytokines to activate TH1 cells
IL-12
IL-18
Which cell type is activated by IL-4?
TH2 cells
IL-15 regulates growth and activity of which type of cell?
NK cells
Which molecule binds to MHCII within cells to prevent binding/presentation of endogenous peptides?
Invariant chain
What does AIRE do?
Transcriptional factor for self-antigen expression in thymus
What does CTLA – 4 do?
Inhibitory receptor for T cell anergy
Antibodies specific to canine SLE
Anti-Sm
Anti-T1
CD1 function
MHC1-like
Presents lipid to T cells
Which cytokines stimulate the liver to produce SAA?
IL-1
IL-6
