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General Pathology > Immunity > Flashcards

Immunity Flashcards

0
Q

What are the three types of RLRs?

A

RIG-1
MDA-5
LPG-2

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1
Q

PRRs in cytosol

A

TLRs
RLR (Rig-1 like receptors)
NLRs (NOD-like receptors)

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2
Q

What is the universal signaling molecule for NFkB?

A

MyD88

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3
Q

Which molecule is associated with the TCR?

A

CD3

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4
Q

Which is the co-stimulated molecule on T cells?

A

CD28

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5
Q

What molecule on the APC binds to the co-stimulator molecule on the T cell?

A

CD80 (syn. B7-1)

CD81 (syn. B7-2)

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6
Q

In which species is the gamma-delta T-cell the most common type?

A

Ruminants and pigs

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7
Q

Double negative (CD4-/CD8-) T cells are rare in all species except ______.

A

Pigs and cattle

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8
Q

Double positive (CD4+/CD8+) T cells are rare in all species except ______.

A

Pigs

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9
Q

Which cytokines are secreted by TH1 cells?

A

IL-2
IFN-gamma
TGF-B

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10
Q

Which cytokines are secreted by TH2 cells?

A

IL-4
IL-5
IL-13

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11
Q

What is the key marker of T Reg cells?

A

CD25

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12
Q

Activated macrophages produce which cytokine to stimulate a TH1 response?

A

IL-12

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13
Q

Cytokines produced by T Reg cells

A

IL-4
IL-10
TGF-B

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14
Q

Transcription signalling molecule for TH1 T cells

A

T-bet

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15
Q

Transcription signalling molecule for TH2 T cells

A

GATA-3

16
Q

Transcription signalling molecule for T-reg cells

A

FoxP3

17
Q

Which cytokines stimulate TH 17 cells?

A

IL-23

18
Q

Cytokines produced by TH 17 cells

A

IL-17

IL-22

19
Q

Most important stimulator of macrophages and dendritic cell development?

A

Colony Stimulating Factor-1

20
Q

Cell types that express MHC II?

A

B cells
Macrophages
Dendritic Cells

21
Q

Molecule secreted by TH1 cells that is a potent macrophage activator.

A

IFN-gamma

22
Q

Cytolytic molecules in natural killer cell granules

A

Perforin

Granzyme

23
Q

Surface markers for NK Cells

A

CD16

CD56

24
Q

Cytokine produced by NK cells & result

A

IFN-gamma -> TH1 bias

25
Q

Cytokine subfamily produced by activated T cells

A

C-C

26
Q

Cytokine subfamily produced by activated macrophages and endothelium

A

CXC

27
Q

Cytokines to activate TH1 cells

A

IL-12

IL-18

28
Q

Which cell type is activated by IL-4?

A

TH2 cells

29
Q

IL-15 regulates growth and activity of which type of cell?

A

NK cells

30
Q

Which molecule binds to MHCII within cells to prevent binding/presentation of endogenous peptides?

A

Invariant chain

31
Q

What does AIRE do?

A

Transcriptional factor for self-antigen expression in thymus

32
Q

What does CTLA – 4 do?

A

Inhibitory receptor for T cell anergy

33
Q

Antibodies specific to canine SLE

A

Anti-Sm

Anti-T1

34
Q

CD1 function

A

MHC1-like

Presents lipid to T cells

35
Q

Which cytokines stimulate the liver to produce SAA?

A

IL-1

IL-6

General Pathology (6 decks)

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