Cell Adaptations Flashcards
Is BAX Pro or anti-apoptosis?
Pro
Is Bcl-2 Pro or anti-apoptosis?
Anti-apoptosis
Is BAK Pro or anti-apoptosis?
Pro
Is Bcl-XL Pro or anti-apoptosis?
Anti
Is MCL-1 Pro or anti-apoptosis?
Anti
Is BAD Pro or anti-apoptosis?
Pro
Is BID Pro or anti-apoptosis?
Pro
Is PUMA Pro or anti-apoptosis?
Pro
P53 activates which apoptosis mediators & effect?
BAX & PUMA
Pro-apoptosis
Transcription factors activated during myocardial hypertrophy
GATA4
NFAT
MEF2
What molecule type is affected in atrophy?
Proteins
Reduced synthesis and increased degradation
BH3-Only sensors
Bim Bid Bad Puma Noxa
What do activated BAX & BAK do?
Form channels in mitochondria membrane -> cytochrome C leakage -> intrinsic apoptosis
What happens to cytoplasmic cytochrome c?
Binds to Apaf-1 -> forms apoptosome -> activates Caspase 9
Intrinsic apoptosis pathway Caspase
Caspase 9
Extrinsic apoptosis pathway Caspase
8
Molecules in Complex that activates necroptosis
RIP1
RIP3
Caspase 8
What key feature distinguishes extrinsic apoptosis from necroptosis?
Caspases are not activated in necroptosis
What goes wrong in Niemann-Pick type C
Lysosomal storage disease due to abnormal cholesterol trafficking
Tay-Sacs
Type and deficiency
GM2 gangliosidosis
Hexosaminidase a-subunit deficiency
Niemann-Pick Dz A& B
Sphingomyelinase defect
Neimann-Pick Type C
NPC gene mutations
Defective lipid transport -> ganglioside accumulates in neurons
Globoid cell Leukodystrophy
B-Galactocerebrosidase Deficiency
GM1
B-galactosidase deficiency