Vancomycin Flashcards
what type of inhibitor
cell wall synthesis inhibitor
vancomycin is a
glycopeptide
what is vancomycin useful in
Bacteremia
meningitis
has strong
gram-positive activity (MRSA)
which is better vancomycins or beta-lactams for MSSA
beta-lactams
vancomysins have worst outcomes
vancomycin has no
gram negative activity
what are the three adverse effects of vancomysin
nephrotoxicity
ototoxicity
vancomycin infusion reaction
what is the mechanism of action for vancomycin
inhibition of cell wall synthesis via binding to a component of the cell wall preventing transpeptidation
what are the three restitances
VISA
VRE
VRSA
what is daptomycin
cell membrane disruptor
daptomycin is a
positively charged daptomycin-calcium complex that bings negatively charged cell membrane
what does the binding of daptomycin cause
depolarization, inhibits dna, rna and protein synthesis
what are mechanisms of resistance to daptomycin
change in membrane charge, decrease in cell wall permeability
what are the spectrums of daptomycin
Staphylococcus spp including (MRSA)
Enteroccus spp including ( VRE)
