Fluoroquinolones Flashcards
1
Q
what type of inhibitor is fluroquinolones
A
dna gyrase
2
Q
what is the mechanism of action for fluoroquinilones
A
inhibits topoisomerase 2 and 4
3
Q
what are the mechanisms of resistance
A
dna gyrase mutation
plasmid mediated resistance
efflux pumps
4
Q
it is well absorbed
A
orally
5
Q
concentration dependent bactericidal activity is
A
peak to mic
6
Q
what use the clinical use
A
gram negative bacteremia
endocardidits- gram negative
7
Q
what is the spectrum of activity for fluroquinolones
A
gram negative bacillary infections
