30s subunits Flashcards
1
Q
what type of inhibitor is 30s, what does it inhibit
A
protein synthesis
2
Q
where does 30s take place
A
30s subunit
3
Q
what two drugs
A
aminoglycosides
tetracyclines
4
Q
what is the mechanism of action for aminoglycosides
A
irreversible inhibition of initiation complex
5
Q
what does the complex cause
A
misreading of mRNA and blocks translocation
6
Q
what does aminoglosides needs for uptake
A
O2
7
Q
synergy of aminoglycosides are
A
low dose
8
Q
what is the spectrum of activity of aminoglysides
A
gram neg bacillary infection
no anearobic activity
