Van Willebrand Factor Disease and DIC Flashcards
1
Q
True or false: VWF disease is the most common inherited bleeding disorder?
A
True
2
Q
What mutation causes VWF disease?
A
Autosomal dominant mutation of VWF gene on chromosome 12
3
Q
How do you diagnose potential vwf disease?
A
Normal PT and increased APTT
normal f8 and f9 assay
Decreased VWF
4
Q
How do you treat VWF disease?
A
Non-curable
Desmopressin (increases release of VWF from endothelial Weibelpalade bodies)
5
Q
How do you treat DIC?
A
Fresh Frozen Plasma (FFP) to replace clotting factors
Platelet transfusions
Cryoprecipitate to replace fibrinogen
6
Q
DIC is a crisis due to trauma, sepsis, malignancy causing massive activation of…
A
coagulation cascade
