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Epilepsy > Valproate > Flashcards

Valproate Flashcards

1
Q

What is the primary mechanism of action of Valproate?

A

Valproate primarily increases the availability of gamma-aminobutyric acid (GABA) in the brain.

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2
Q

True or False: Valproate is used to treat epilepsy.

A

True

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3
Q

What are common side effects of Valproate?

A

Common side effects include nausea, vomiting, drowsiness, and tremors.

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4
Q

Fill in the blank: Valproate is often used as a treatment for __________ disorders.

A

bipolar

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5
Q

List one brand name for Valproate.

A

Depakote

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6
Q

What is the recommended starting dose of Valproate for pediatric patients?

A

The typical starting dose for pediatrics is 10-15 mg/kg/day.

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7
Q

True or False: Valproate can cause liver toxicity.

A

True

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8
Q

What is a serious side effect of Valproate that requires monitoring?

A

Hepatotoxicity

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9
Q

Multiple choice: Which of the following is NOT a use of Valproate? A) Epilepsy B) ADHD C) Bipolar Disorder

A

B) ADHD

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10
Q

What is the maximum recommended dose of Valproate for adults?

A

The maximum recommended dose is typically 60 mg/kg/day.

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11
Q

True or False: Valproate is contraindicated in pregnancy.

A

True

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12
Q

What should be monitored regularly in patients taking Valproate?

A

Liver function tests

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13
Q

Fill in the blank: Valproate can lead to __________, a decrease in blood platelets.

A

thrombocytopenia

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14
Q

What is the primary pharmacokinetic characteristic of Valproate?

A

Valproate is highly protein-bound.

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15
Q

List another brand name for Valproate.

A

Depakene

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16
Q

What is the typical concentration of Valproate in a 10 ml solution?

A

The concentration is typically 250 mg/5 ml.

17
Q

True or False: Valproate can be used for migraine prophylaxis.

A

True

18
Q

What is the effect of Valproate on neurotransmitter levels?

A

It increases GABA levels and decreases glutamate levels.

19
Q

Multiple choice: Which side effect is most associated with Valproate? A) Weight loss B) Hair loss C) Increased appetite

A

B) Hair loss

20
Q

Fill in the blank: Valproate is classified as an __________ agent.

A

anticonvulsant

21
Q

What is the mechanism by which Valproate enhances GABA?

A

It inhibits the enzyme GABA transaminase.

22
Q

True or False: Valproate is effective in treating absence seizures.

A

True

23
Q

What should be considered when prescribing Valproate to women of childbearing age?

A

The risk of teratogenic effects.

24
Q

List one indication for Valproate use in pediatric patients.

A

Treatment of epilepsy.

25
Q

What is the typical loading dose of Valproate for acute seizures?

A

The loading dose is usually 15-30 mg/kg.

26
Q

True or False: Valproate can cause gastrointestinal disturbances.

A

True

Epilepsy (7 decks)

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