Valproate Flashcards
What is the primary mechanism of action of Valproate?
Valproate primarily increases the availability of gamma-aminobutyric acid (GABA) in the brain.
True or False: Valproate is used to treat epilepsy.
True
What are common side effects of Valproate?
Common side effects include nausea, vomiting, drowsiness, and tremors.
Fill in the blank: Valproate is often used as a treatment for __________ disorders.
bipolar
List one brand name for Valproate.
Depakote
What is the recommended starting dose of Valproate for pediatric patients?
The typical starting dose for pediatrics is 10-15 mg/kg/day.
True or False: Valproate can cause liver toxicity.
True
What is a serious side effect of Valproate that requires monitoring?
Hepatotoxicity
Multiple choice: Which of the following is NOT a use of Valproate? A) Epilepsy B) ADHD C) Bipolar Disorder
B) ADHD
What is the maximum recommended dose of Valproate for adults?
The maximum recommended dose is typically 60 mg/kg/day.
True or False: Valproate is contraindicated in pregnancy.
True
What should be monitored regularly in patients taking Valproate?
Liver function tests
Fill in the blank: Valproate can lead to __________, a decrease in blood platelets.
thrombocytopenia
What is the primary pharmacokinetic characteristic of Valproate?
Valproate is highly protein-bound.
List another brand name for Valproate.
Depakene
What is the typical concentration of Valproate in a 10 ml solution?
The concentration is typically 250 mg/5 ml.
True or False: Valproate can be used for migraine prophylaxis.
True
What is the effect of Valproate on neurotransmitter levels?
It increases GABA levels and decreases glutamate levels.
Multiple choice: Which side effect is most associated with Valproate? A) Weight loss B) Hair loss C) Increased appetite
B) Hair loss
Fill in the blank: Valproate is classified as an __________ agent.
anticonvulsant
What is the mechanism by which Valproate enhances GABA?
It inhibits the enzyme GABA transaminase.
True or False: Valproate is effective in treating absence seizures.
True
What should be considered when prescribing Valproate to women of childbearing age?
The risk of teratogenic effects.
List one indication for Valproate use in pediatric patients.
Treatment of epilepsy.
What is the typical loading dose of Valproate for acute seizures?
The loading dose is usually 15-30 mg/kg.
True or False: Valproate can cause gastrointestinal disturbances.
True
