Vagina

Question 1

OF women with VAIN - what % will have had CIN currently or in the past?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 1

40% currently and 52% overall

40 - 90% in other studies

Question 2

What % of VAIN is in the upper 1/3 of the vagina?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 2

96%

Question 3

How often are multiple lesions present in VAIN?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 3

~ 50%

Question 4

In observation of VAIN I what % will have regression

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 4

48%

Question 5

In Laser Rx of VAIN I what % will have regression ?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 5

75%

Question 6

In excision of VAIN I - what % of women will have regression?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 6

77%

Question 7

In VAIN I Rx with 5 - FU what % of women will have regression?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 7

46% ( less than ovservation)

Question 8

in VAIN II - 5% were followed up with observation and how many regressed spontaneously?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 8

~ 50%

Question 9

What was the rate of recurrence in VAIN II Rx with Laser and Excision?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 9

Laser - 84% regressed without recurrence

Excision - 75% regressed without recurrence

Question 10

In VAIN III - What was the difference in regression between LASER and excision
2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 10

LASER 74%

Excision 67.5 % no SS

Question 11

in VAIN III - 5% Rx with 5 FU - rate of regression was?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 11

0%

Question 12

In VAIN III - 1. 6% of women were Rx with Radiotherapy. What is the risk of recurrence in that group?
2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 12

100% regressed and 0% recurred.

Question 13

During follow up for VAIN - how many women progressed to invasive cancer?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 13

3.2% all of which were VAIN III

Question 14

What factors are associated with recurrence in VAIN after treatment?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 14

High-risk HPV

Treatment other than Excision or LASER

Question 15

After treatment for VAIN - what is the likelihood of recurrence in women who had previously regressed?

2018 JGO article from Sth Korea - 576 women with VAIN I - III

Answer 15

17%

Question 16

In a Meta-analysis of 5% imiquimod for VAIN. The likelihood of complete response was?

Answer 16

76.5% (95% CI 59.4–98.5)

and 52.5% (95% CI 29.5–93.6) respectively

Question 17

In a Meta-analysis of women treated with 5% imiquimod for VAIN the rate of HPV clearance was?

Answer 17

52.5% (95% CI 29.5–93.6)

Question 18

What is a standard regiment for 5% imiquimod for VAIN?

Answer 18

Apply to vagina 3 x a week for 8 weeks

Question 19

What is stage IA Vaginal Ca

Answer 19

Only in the vagina and no larger than 2cm

Question 20

What is stage IB Vaginal Ca

Answer 20

Confined to the Vagina and >2cm in size.

Question 21

What is stage IIA Vaginal Ca

Answer 21

Invades through the vagina but not to the side wall and is smaller than 2cm

Question 22

What is stage IIB Vaginal Ca

Answer 22

Invades throught the vagina but not to the side wall and is >2cm

Question 23

What is stage III Vaginal Ca

Answer 23

Cancer of any size that leads to hydronephrosis.
With or without nodal disease but no distant mets

Question 24

What is stage IVA in vaginal Ca

Answer 24

Invades bladder or rectum or is growing out of the pelvis.

Question 25

What is stage IVB vaginal Ca

Answer 25

Distant mets