Vaccines Flashcards
Adenovirus?
NON-ATTENUATED, given to military recruits
Typhoid? admin?
Ty21a, oral
Ty21a, oral?
Typhoid, live attenuated
Polio, Sabin?
live attenutated, ORAL
Varicella (chickenpox)?
live attenuated
Smallpox?
live attenuated
BCG?
live attenuated
Yellow fever?
live attenuated
Influenza, intranasal?
live attenuated
MMR?
live attenuated
Rotavirus?
live attenuated
Rabies?
killed/inactivated
Influenza injection?
killed/inactivated
polio, salk?
killed/inactivated
HAV?
killed/inactivated
typhoid, Vi polycacharide, intramuscular?
killed/inactivated
HBV(antigen HBsAg)?
Subunit
HPV (6, 11, 16)?
Subunit
acellular pertusis (aP)?
Subunit
N. meningitidis?
Subunit
S. pneumonia?
Subunit
H. influenza B?
Subunit
c. tetani?
toxoid
C. diphteria?
toxoid
m/os loses pathogenicity, but retains capacity for transient growth within inoculated host?
live attenuated
live attenuated what systems response?
CELLULAR AND HUMORAL
live attenuated contraindicated?
in pregnant and immunodeficiency, because can revert to virulent form
MMR and varicella can be given to HIV without evidence of immunity if CD4 > 200
.
Pathogen is inactivated by heat or chemicals. maintain epitope - important for immune response.?
killed/inactivated
killed/inactivated - what response?
ONLY HUMORAL
what induces strong, life long response?
live attenuated
what is safer than live?
killed/inactivated
cons of inactivated?
weaker immune response, booster shoots needed
Include only antigens that best stimulaet the immune system?
subunit
subunit pros?
lower chance of adverse reactions
subunit cons?
expensive, weaker immune response
denatured bacterial toxin with intact receptor binding?
toxoid
stimulated immune response to make antibodies without potential for causing disease?
toxoid
toxoid pros?
protects agains toxins
toxoid cons?
antitoxin levels decrease with time, may require booster
