Autoimmune Flashcards

1
Q

What blood changes are seen in SLE? (2)

A

Pancytopenia (anemia - hemolytic)

Hypocomplementenemia (C3, C4)

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2
Q

Antibodies in SLE? (3)

A

ANA - sensitive, but not specific

Anti-dsDNA and anti-Sm (specific, but not sensitive)

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3
Q

Serosal changes in SLE? (3)

A

Serositis: pleurisy, pericarditis and peritonitis

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4
Q

Skin changes in SLE? (2)

A

Face butterfly rash and photosensitivity

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5
Q

How manifest artritis in SLE?

A

symetric, migratory

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6
Q

Constitutional symptoms in SLE? (3)

A

Fever, fatigue, weight loss

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7
Q

What neurologic changes in SLE? (2)

A

Cognitive dysfunction and seizures

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8
Q

What is the course of SLE symptoms?

A

Gradual onset

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9
Q

Renal manifestation in SLE?

A

Proteinuria, elevated creatinine, red casts (glomerulonephritis)

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10
Q

What may be 2 reasons of anemia in SLE?

A

Anemia of chronic inflammation.

Pancitopenia due to IgG autoantibodies against RBCs receptors –> II hypersensitivity

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11
Q

What causes pancytopenia in SLE?

A

Autoantibodies against RBCs, platelets and leukocytes

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12
Q

Lupus nephritis - what hypersensitivity?

A

Type III

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13
Q

What are changes in inflammatory markers in SLE? (2)

A

incr. CRP and ESR

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