Autoimmune Flashcards
What blood changes are seen in SLE? (2)
Pancytopenia (anemia - hemolytic)
Hypocomplementenemia (C3, C4)
Antibodies in SLE? (3)
ANA - sensitive, but not specific
Anti-dsDNA and anti-Sm (specific, but not sensitive)
Serosal changes in SLE? (3)
Serositis: pleurisy, pericarditis and peritonitis
Skin changes in SLE? (2)
Face butterfly rash and photosensitivity
How manifest artritis in SLE?
symetric, migratory
Constitutional symptoms in SLE? (3)
Fever, fatigue, weight loss
What neurologic changes in SLE? (2)
Cognitive dysfunction and seizures
What is the course of SLE symptoms?
Gradual onset
Renal manifestation in SLE?
Proteinuria, elevated creatinine, red casts (glomerulonephritis)
What may be 2 reasons of anemia in SLE?
Anemia of chronic inflammation.
Pancitopenia due to IgG autoantibodies against RBCs receptors –> II hypersensitivity
What causes pancytopenia in SLE?
Autoantibodies against RBCs, platelets and leukocytes
Lupus nephritis - what hypersensitivity?
Type III
What are changes in inflammatory markers in SLE? (2)
incr. CRP and ESR