INTERLEUKINS TABLE UW Flashcards
what cytokines are acute? 3
IL-1, IL-6, TNF-alfa
what cytokines are late?2
IL-8, IL-12
Source of IL-1?
Macrophages (/monocytes)
Other cells: endothelial cells, dendritic cells, B cells, fibroblasts
Source of IL-2?
all activated T cells (mainly CD4)
Source of IL-3?
all activated T cells
Source of IL-4?
Th2 cells (+mast cells)
Source of IL-5?
Th2 cells (+mast cells)
Source of IL-6?
Macrophages (/monocytes)
Source of IL-7?
Adventitial reticular cells
Source of IL-8?
Macrophages
T cells
Other cells: endothelial cells and smooth muscle cells
Source of IL-10?
Th2 (main)
Treg cells
Macrophages
Source of IL-12?
Macrophages
Most important anti-inflammatory interleukin?
IL-10
Most important proinflammatory interleukins?
IL-1 and 6 (and TNF-α)
Functions of most important proinflammatory interleukins/
endogenous pyrogens (fever) and main mediators of sepsis
IL-1 and 6 (and TNF-α). Three functions?
fever, inflammation and shock
Osteoclast-activating factor?
IL-1
Dysregulation of IL-1 leads to ….
Dysregulation of IL‑1 in cartilage leads to damage and osteoarthritis.
Induces expression of adhesion molecules in the endothelium? ICAM
IL-1, TNF-alpha
Mediates septic shock by activating the endothelium, which causes vascular leakage and recruitment of white blood cells?
TNF-alpha
Causes cachexia?
TNF-alpha
Causes vascular leak?
TNF-alpha
Main in mediation of septic shock? from FA/AMBOSS
TNF-alpha
Cytotoxic and inhibits carcinogenesis of certain tumors?
TNF-alpha