Vaccinations/ Immunizations Flashcards
DTaP vaccine is administered to what age group
Young children
Explain the dosing series fro DTaP in young children
5 dose series by age of 6 yrs
A dose @ 2, 4, & 6 mos
A dose at 15 through 18 mos
A dose at 4 through 6 yrs
Tdap vaccine is given to what age groups?
Preteens → 11 through 12
Pregnant women → 27-36th week of each pregnancy
Adults → anytime to those who haven’t received
What age groups does H. influenzae type b (hib) generally affect?
Occurs mostly in babies & children < 5 yrs
OR
Adults 65 yrs or older
H. influenzae type b can affect people with certain medical conditions including:
Sickle cell disease
Asplenia
HIV infection
Ab & complement deficiency syndromes
Pts undergoing cancer Tx
Is H. influenzae type b (hib) vaccine the same as the annual flu shot?
no
H. Influenzae type b (hib) can cause what 2 infections in infants & young children?
Meningitis &/ or penumonia
Hib vaccination schedule for infants & children:
2, 4, 6 mos & 12 through 15 mos
Hib vaccination schedule for adults:
1 to 3 doses depending on indication
How is Hepatitis A typically contracted
Fecal-oral route → contaminated drinking water/ milk or shellfish in contaminated water
What is the incubation period for Hepatitis A
14-28 days → hard to determine when exposed
Hepatitis A can lead to ____ liver & ____
Fulminant liver & death
Who is hepatitis A vaccine recommended for?
International travelers to regions with poor sanitation / high incidence of Hep A
Children @ 12 & 18 mos
Hepatitis A is a ____ dose series
2 dose series
If Hepatitis B is not treated it can lead to
Cirrhosis
Liver cancer
Liver failure
Who is at increased risk for contracting Hepatitis B
IV drug users
Multiple sexual partners
Homosexual males
HC workers → needlesticks/ taking care of those with Hep B
Hepatitis B vaccination schedule for infants & children
3 dose series
0, 1-2 mos, 6-18 mos
When is administration of a 4 dose Hep B vaccine permitted?
When a combo vaccine containing Hep B is used after the birth dose
What is the minimum age for the final (3rd or 4th) dose of Hep B vaccine?
24 mos
What do Hepatitis B titers determine?
Whether there are memory or no memory cells → if a pt still has immunity
Why is HPV vaccine administered?
To prevent certain types of cancers (cervical) & infections
How many strains of HPV can cause cancer?
13
What is the vaccine schedule for HPV vaccine?
2-3 dose series
Starts at age 11-12 for both girls & boys
What is the earliest age HPV vaccine can be given & why?
As early as 9 yrs because of sexual abuse
By what age should HPV vaccines be completed?
Before age 15
HPV vaccine is NOT recommended after what age?
26
What are the three FDA approved HPV vaccines?
Gardasil
Cervarix
Gardasil 9
Gardasil 9
Only used in the US
Protects against 9/13 strains
now can be used for both boys & girls
What patients should not receive HPV vaccine?
HPV should NOT be given during pregnancy
Annual influenza vaccine helps protects against?
Influenza types A, B, & C
Influenza
Highly contagious; spread through respiratory droplets
Influenza vaccine schedule
Recommended for all ages (6 mos or >) annually
Influenza vaccines may be ____ or ___-____
inactivated or live-attenuated
experts predict what the predominant strain might be for the next year
Influenza vaccine should be used with caution in those with…
egg allergies
Influenza vaccine can take ~ 2 weeks for ____ ____ to kick in
Immune system → meaning you could get the flu within that time
Getting the flu vaccine decreases risk of …
heart attack by 30%
Influenza is related to ____
Inflammation
Rubella
German measles
Milder version of regular measles
-rash fades faster
Mumps
Contagious viral infection that causes painful swelling in salivary glands in cheek & jaw
Measles
Highly contagious viral infection that causes rash, fever, runny nose, cough, & red eyes
How is MMR spread?
respiratory droplets or sharing food/ drinks with infected person
What are two vaccines required for children to go to school?
MMR
DTaP
MMR vaccine schedule for children
1st dose → 12-15 mos
2nd dose → 4 thru 6 yrs
What is another vaccines associated with MMR that children can get?
MMRV → protects against measles, mumps, rubella, & varicella
MMRV vaccine is licensed for use in what age groups?
Children who are 12 mos through 12 yrs of age
Who else should be up to date on their MMR vaccines?
Teens & adults
What has been a controversial finding associated with MMR vaccine?
That MMR is linked to autism → NO evidence that supports this
Meningitis B
Disease caused by the bacteria → neisseria meningitidis
What can meningitis B lead to?
Meningitis → infection of meninges of the brain & spinal cord & infection of the blood
How is meningitis B spread?
Respiratory droplets → infected person coughs or sneezes
Lives on things touched by infected person
Through kissing, or sharing drink/ food w/ infected person
Meningitis B vaccine is used to prevent infection caused by
Serogroup B meningococcal bacteria
Leading risk of meningitis B in what age group?
Young adult teens
What is the likelihood of dying from bacterial meningitis
High likelihood
Meningitis B vaccine schedule
May be given at 10 → w/ booster at 16 yrs old
Recommended for 19-23 yrs → 2-3 dose series
Adults at increased risk for meningococcal disease
Meningitis B 2-3 dose series is dependent on what two things
vaccine & indication
What serogroups cause most meningococcal diseases
Serogroups A, C, W, & Y
What vaccine protects against meningococcal A, C, W, Y strains of bacteria?
Meningococcal (MCV04-ACYW)
Meningococcal (MCV04-ACYW) vaccine schedule
Two dose series for adolescents 11 through 18
1st dose → 11/ 12 yrs w/ booster dose at 16
Meningococcal vaccine is recommended for anyone with
Complement component deficiency
Taking complement inhibitor med
Have a damaged spleen or had a splenectomy
Have HIV
traveling to or residing in countries where disease is common
Part of population at increased risk for outbreak
Complement component deficiency
Rare immune disorder
List 2 examples of complement inhibitor medications
Soliris or ultomiris
Who are considered populations at risk for meningococcal outbreaks?
College freshman living in dorms
Military recruits
What was the most feared childhood communicable disease during the 1950s?
Polio (poliomyelitis)
Polio could lead to ____
Paralysis
What was used for people Dx with polio who had trouble breathing from being paralyzed?
Iron lung
When was polio eliminated from the US?
1979
What is the 3rd vaccination needed for children to go to school in PA?
Polio vaccine
Polio vaccine schedule for children
Starting at 2 mos, 4 mos, 6 through 18 mos, & 4-6 yrs
A polio lifetime booster dose can be administered to?
Adults at increased risk of exposure to poliovirus & who have previously completed the vaccine series
What form of vaccine is polio?
Inactivated form
Polio (poliomyelitis):
____ vaccine dosing is no longer available in the US
Oral
Pneumococcal conjugate (Prevnar-13 or PCV13)
Protects against 13 types of penumococcal bacteria & ear infections
Pneumococcal conjugate is recommended for
All children < 2 yrs
People 2 yrs or > with certain medical conditions
Adults 65 yrs or > can get PCV13
Pneumococcal conjugate vaccine schedule children (4 dose series)
2, 4, 6, & 12 through 15 mos
Pneumococcal conjugate vaccine schedule children (single dose)
6-17 years
Pneumococcal conjugate vaccine for adults
If needed they only get a single dose
Pneumococcal polysaccharide (PPSV-23 or pneumovax 13) recommended for
All adults 65 yrs or >
People 2-64 yrs with certain medical conditions
Adults 19-64 yrs who smoke cigarettes
Why should ALL adults 65 yrs or > get the pneumococcal polysaccharide vaccine?
Pneumonia is more prevalent in older population
Pneumococcal polysaccharide vaccine schedule
ALL adults → 1-2 doses, depending on indications
Adults 65 yrs or > get 1 dose
Rotavirus
Contagious viral illness causing severe, watery diarrhea
What illness is the leading cause of childhood death worldwide?
Rotavirus
Rotavirus Vaccine schedule
Two or three dose series beginning at 2 mos
RotaTeq vaccine
Given in 3 doses → 2, 4, & 6 mos
Rotarix
Given in 2 doses → 2 & 4 mos
When should the first dose of either Rotavirus vaccine be given?
Before 15 weeks of age
By what age should children have received all doses of rotavirus vaccine?
Before they turn 8 mos old
What route is the Rotavirus vaccine administered?
Orally
What form of vaccine is the Rotavirus vaccine?
Live-attenuated → will NOT cause disease
Varicella
AKA: chicken pox
Highly contagious disease caused by varicella-zoster virus (VZV)
What helps chicken pox to spread?
Purulent pus
When is the only time chicken pox are not contagious?
When they scab over → takes a while
Varicella vaccine schedule
Two dose series
1st dose → 12-15 mos
2nd dose → 4-6 yrs
Varicella vaccine schedule for adolescents & adults (w/o evidence of immunity)
Receive 2 dose series 4-8 weeks apart
What vaccine form is varicella vaccine?
Live-attenuated → will NOT get disease
Varicella can be given with what other vaccine?
MMR → known as MMRV
What is the 4th vaccine children need to attend school?
Varicella vaccine
Varicella-zoster virus
AKA: Shingles
Painful rash that occurs in people who HAVE had chicken pox
Varicella-zoster virus lies dormant where?
Just outside the spinal cord → may never affect you
Varicella-zoster virus is ____ of the virus
Reactivation
Varicella-zoster virus follows ___ ____
Nerve endings → get it on the face or trunk
What type of pain does Varicella-zoster virus cause?
Hot, burning, neuropathic type pain
Transmission of Varicella-Zoster virus
Airborne droplets or direct contact with open blisters
Varicella-zoster vaccine schedule
Shingrix → vaccine
2 dose series → 2-6 mos apart for adults > 50 yrs
Varicella-zoster virus has an _____ response
Inflammatory response
affects blood vessels & can cause cardiac problems
Live-attenuated vaccines
Microorganism in vaccine is alive but has been weakned (attenuated)
Explain the immune response of Live-attenuated vaccines
Virtually identical to that produced by the infection
How many doses do most live vaccines require?
1-2 doses
Live-attenuated vaccines should be avoided in what types of patients?
Those with immunodeficiency
List examples of Live-attenuated vaccines
MMR
Varicella
Typhoid
Cholera
BCG → To prevent Tb
What live-attenuated vaccines are given if traveling to a country with high incidence of disease?
Dengue
Yellow fever
Smallpox
Ebola
Adenovirus
Non-live vaccines
Inactivating microbe or vaccine produced through genetic technology
Non live vaccines can be composed of ____ or ____ of the organism
whole or part
Non live vaccines can be either ____ based or ____ based
protein based or polysaccharide based
Given an example of a protein based non live vaccine
Toxoids
Which vaccine requires multiple doses to achieve an immune response
Non-live vaccines
Non live vaccines may also require a supplemental _____ dose
booster
List examples of non live vaccines
Polio
Hepatitis A
Some influenza vaccines
Pertussis
H. influenzae type B
Pneumococcal
Meningococcal
Rabies
Anthrax
Japanese encephalitis
Adverse effects of vaccines can be associated with ____ or ____ responses
Immune or inflammatory responses
Vaccines adverse effects:
Localized
up to 80%
Pain; swelling; redness at injection site
Typically mild Sx
Vaccines adverse effects:
Systemic
fever; malaise; muscle pain; H/A
Ex. fevers from COVID vaccine
What is a rare adverse effect of vaccines?
Severe hypersensitivity
If someone has an adverse reaction to a vaccine who can call to report it?
ANYONE
Ex. patient, nurse, HC provider, etc
Contraindications of vaccines
Presence of immune deficiency
Pregnancy
Known allergy to any vaccine components
Pt receiving immunoglobulin
Pts who received blood or blood products within last 3 mos
Acute infection
Vaccines should not be given with what 2 medications?
Immunosuppressants
Corticosteroids
Caution to giving vaccines in
Children with Hx of febrile convulsions or cerebral injury
Any condition in which potential fever could be contagious
Vaccine patient education
ALL should be given VIS
(vaccine information sheet)