v basic pharm (cloting)

Question 1

unfractioned heparin

Answer 1

• heparin (anticoagulant)
• non specific binding
• increases AT-III activity

Question 2

enoxaparin

Answer 2

• LMW heparin (anticoagulant)

- increases AT-III activity (X > thrombin)

Question 3

dalteparin

Answer 3

• LMW heparin (anticoagulant)

- increases AT-III activity (X > thrombin)

Question 4

fondaparinux

Answer 4

• heparin derived (anticoagulant)

- pure Xa inhibitor (thru AT-III)

Question 5

lepiruidin

Answer 5

• direct thrombin inhibitor (anticoagulant)
• AT-III independent
• binds thormbin:fibrin complex
• hepatic clearance

Question 6

argatroban

Answer 6

• direct thrombin inhibitor (anticoagulant)

- renal clearance

Question 7

dabigatran

Answer 7

• direct thrombin inhibitor (anticoagulant)

- renal clearance

Question 8

rivaroxaban

Answer 8

• direct factor Xa inhibitor (anticoagulant)

- renal clearance

Question 9

recombinant tPA

Answer 9

• thrombolytic (anticoagulant)

- converts plasminogen to plasmin, which degrades clot

Question 10

warfarin

Answer 10

• vitamin K antagonist (anticoagulant)

- blocks factors: 2, 7, 9, 10, protein C/S

Question 11

aspirin

Answer 11

• anti platelet agent (anticoagulant)
• irreversibly inhibits COX2
• decreased thromboxane
• impaired aggregation

Question 12

clopidogrel

Answer 12

• anti platelet agent (anticoagulant)
• irreversibly inhibits PGY12 receptor of ADP
• inhibits platelet aggregation

Question 13

prasugrel

Answer 13

• anti platelet agent (anticoagulant)

- rapid onset

Question 14

NSAID

Answer 14

• anti platelet agent (anticoagulant)
• reversibly inhibits COX2
• decreased thromboxane
• inhibits platelet aggregation

Question 15

abciximab

Answer 15

• GPIIb/IIIa antagonist (anticoagulant)
• reversibly inhibits platelet aggregation
• binding site of fibrinogen between platelets

Question 16

vorapaxar

Answer 16

• PAR-1 antagonist (anticoagulant)

- blocks thrombin related platelet aggregation

Question 17

dipyridamole

Answer 17

-PDE5 inhibitor (anticoagulant)
-PDE normally breaks down cAMP
(increased cAMP decreases platelet aggregation response to ADP)

Question 18

vitamin K

Answer 18

• pro coagulant

- promotes production of factors 2, 7, 9, 10, protein C/S

Question 19

recombinant factor VIIa

Answer 19

• pro coagulant

- extrinsic pathway

Question 20

desmopressin acetate (DDAVP)

Answer 20

-promotes release of stored vWF from vascular endothelium

Question 21

aminocaproic acid

Answer 21

• anti fibrinolytic

- used in management of bleeds as a result of thrombolytic therapy