v basic pharm (cloting) Flashcards
1
Q
unfractioned heparin
A
- heparin (anticoagulant)
- non specific binding
- increases AT-III activity
2
Q
enoxaparin
A
- LMW heparin (anticoagulant)
- increases AT-III activity (X > thrombin)
3
Q
dalteparin
A
- LMW heparin (anticoagulant)
- increases AT-III activity (X > thrombin)
4
Q
fondaparinux
A
- heparin derived (anticoagulant)
- pure Xa inhibitor (thru AT-III)
5
Q
lepiruidin
A
- direct thrombin inhibitor (anticoagulant)
- AT-III independent
- binds thormbin:fibrin complex
- hepatic clearance
6
Q
argatroban
A
- direct thrombin inhibitor (anticoagulant)
- renal clearance
7
Q
dabigatran
A
- direct thrombin inhibitor (anticoagulant)
- renal clearance
8
Q
rivaroxaban
A
- direct factor Xa inhibitor (anticoagulant)
- renal clearance
9
Q
recombinant tPA
A
- thrombolytic (anticoagulant)
- converts plasminogen to plasmin, which degrades clot
10
Q
warfarin
A
- vitamin K antagonist (anticoagulant)
- blocks factors: 2, 7, 9, 10, protein C/S
11
Q
aspirin
A
- anti platelet agent (anticoagulant)
- irreversibly inhibits COX2
- decreased thromboxane
- impaired aggregation
12
Q
clopidogrel
A
- anti platelet agent (anticoagulant)
- irreversibly inhibits PGY12 receptor of ADP
- inhibits platelet aggregation
13
Q
prasugrel
A
- anti platelet agent (anticoagulant)
- rapid onset
14
Q
NSAID
A
- anti platelet agent (anticoagulant)
- reversibly inhibits COX2
- decreased thromboxane
- inhibits platelet aggregation
15
Q
abciximab
A
- GPIIb/IIIa antagonist (anticoagulant)
- reversibly inhibits platelet aggregation
- binding site of fibrinogen between platelets
