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AIM - Heme/Onc > Dumb Shit I Keep Forgetting > Flashcards

Dumb Shit I Keep Forgetting Flashcards

1
Q

CD20+

A

B cells

exception: Reed-Sternberg cells

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2
Q

CD34+

A

HSC

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3
Q

CD38+

A

lymphoid lineage

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4
Q

CD33+

A

myeloid lineage

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5
Q

CD56+

A

NK (lymphoid)

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6
Q

CD13+

A

granulocytes

monocytes

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7
Q

t(14;18)

A

BCL-2

Follicular lymphoma

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8
Q

t(11;14)

A

Cyclin D1

Mantle cell lymphoma

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9
Q

t(8;14)

A

C-Myc

Burkitt’s Lymphoma

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10
Q

t(3;14)

A

BCL-6

Diffuse large B cell lymphoma

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11
Q

indolent NHL

A

follicular
small lymphocytic lymphoma
marginal zone lymphoma
Waldstrom Macroglob

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12
Q

aggressive NHL

A

mantle cell
Burkitts
Diffuse large B cell
HIV associated

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13
Q

Protein C/S

A

VIII
V

(8,5)

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14
Q

AT-III

A

II, VII, IX, X, XI

2,7,9,10,11

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15
Q

TFPI

A

TF:VII complex

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16
Q

what does thrombin make

A

fibrin (I), V, VIII, IX, XI, 13

1, 5, 8, 11, 13

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17
Q

congenital causes of aplastic anemia

A

1) Fanconi
2) Schwachman-Diamond
3) Dyskeratosis Congenita
4) Amegakaryocytic Thrombocytopenia

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18
Q

high basophils

A

CML

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19
Q

increased monocytes

A
  • chronic infection: TB
  • chronic inflammation: sarcoid
  • chronic neutropenia
  • recovery from neutropenia
  • preleukemia
  • myeloproliferative syndrome
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20
Q

CGD test

A

nitroblue-tetrazolium test (NBT) is NEGATIVE

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21
Q

Job’s Syndrome

A
  • Hyperimmunoglobulin E
  • recurrent infections
  • AD
  • STAT3 gene

DEFECT IN CHEMOTAXIS

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22
Q

Dohle Bodies

A

cytoplasmic inclusions, ribosome rich ER

sepsis, G-CSF use

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23
Q

reticulocyte index

A

retic count x (pt Hct/40)

RI>2 in pt with anemia if marrow is responding properly

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24
Q

anemia of chronic disease lab results

A

decreased serum iron (hidden from bacteria)
Normal/increased ferritin
Decreased TIBC

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25
Q

B12 stores

A

years

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26
Q

folate stores

A

months

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27
Q

B12 absorption

A

intrinsic factor + distal ileum

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28
Q

folate absorption

A

duodenum

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29
Q

pernicious anemia

A

Abs against intrinsic factor
-deficiency of B12

hypersegmented giant neutrophils (megaloblastic anemia)

dyssynchrony

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30
Q

each mL of packed red blood cells contains ___ iron

A

1 mg

each mL of packed red blood cells contains 1 mg iron

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31
Q

infectious mononucleosis associated with

A

cold agglutinin disease

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32
Q

epispdic hemolysis, after antibiotics

A

oxidant induced

G6PD

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33
Q

thrombin time

A

fibrinogen –> fibrin

the activity of thrombin

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34
Q

PAI-1

A

plasminogen activator inhibitor

35
Q

neurologic sx in an ill appearing patient

A

TTP

36
Q

AML Tx

A

Cytrabine + Anthracycline

37
Q

APL Tx

A

ATRA

ATO

38
Q

CML Tx

A

Imatinib

39
Q

Polycythemia Vera Tx

A

Phlebotomy
hydroxyurea
JAK2 inhibitor

40
Q

essential thrombocythemia Tx

A

hydroxyurea
JAK2 inhibitor
aspirin

41
Q

primary myelofibrosis Tx

A

HSCT

JAK 2 inhibitor

42
Q

MDS Tx

A

HSCT
Growth factors
Hypomethylating agents
Immune modulators

del(5q) - Lenolinamide

43
Q

Hodgkins Tx

A

ABVD

Anthracycline
Bleomycin
Vinca
Dacarbazine

44
Q

Non-Hodgkins Tx

A

Radiation + Chemo/
Rituximab

CHOP
(cyclophosphamide, antracycline, vincristine, prednisone)

45
Q

HIV associated lymphoma Tx

A

HAART

46
Q

CLL Tx

A

Fludarabine + Rituximab

Ibrutinib

47
Q

Multiple Myeloma Tx

A

Melphalan

Triplet Therapy:
IMiD, proteosome inhibitor, dexamethasone

48
Q

Plasma cell leukemia Tx

A

Palliative

49
Q

Light chain amyloidosis Tx

A

similar to mutiple myeloma

melphalan, imid, proteosome inhibitor, dexamethasone

50
Q

cryoglobulinemia Tx

A

cold avoidance

plasmapheresis

51
Q

ovarian cancer

A

BRCA gene

52
Q

thyroid cancer

A

PTEN, RET

53
Q

colon cancer

A

APC
LKB1
MMR

54
Q

melanoma

A

p16
CDKN2
Rb

55
Q

flow cytometry

A

CD markers of a cell

56
Q

IHC

A

kappa/lambda chains

57
Q

if thyroid involved, think

A

radiation

58
Q

idarucizumab

A

reversal agent for dabigatran

59
Q

andexanet alpha

A

reversal of rivaroxaban (factor Xa inhibitor)

60
Q

AML favorable

A

t(8;21)
inv(16)
t(15;17)

61
Q

AML unfavorable

A

11q23 translocation
del5
del7

62
Q

ALL favorable

A

t(12,21)

63
Q

ALL unfavorable

A

t(9;22)
t(4;11)
11q23 translocation

64
Q

ABVD toxicity

A

A: cardiac
B: pulmonary
V: neurologic, hematologic
D (dacarbazine): hematologic

65
Q

bimodal distribution

A

HL

66
Q

sequential LN involvement

A

HL

67
Q

lenalidomide

A

myeloma, MDS

68
Q

poor risk factors CLL

A

Rai stage 3/4

17p deletion

69
Q

5q deletion

A

MDS
Favorable

Tx: lenalidomide

70
Q

Txs that can cause MDS

A

alkylators

Topoisomerase Tx

71
Q

interferon

A

MPN

72
Q

PSA

A

early detection

73
Q

AFP

A

diagnostic

74
Q

tumor size

A

prognostic

75
Q

ER, HER

A

predictive

76
Q

KRAS

A

predictive

77
Q

CEA

A

therapeutic monitor

78
Q

BRCA

A

risk stratification

79
Q

EMA

A

epithelial membrane antigen

carcinomas

80
Q

CD45

A

luekocyte common antigen

lymphoma

81
Q

chromogranin, synaptophysin

A

neuroendocrine tumor

82
Q

NSE

A

neuroendocrine tumor

83
Q

HCG, AFP

A

germ cell tumor

84
Q

vimentin

A

soft tissue sarcoma

AIM - Heme/Onc (9 decks)

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