- chronic infection: TB - chronic inflammation: sarcoid - chronic neutropenia - recovery from neutropenia - preleukemia - myeloproliferative syndrome

- Hyperimmunoglobulin E - recurrent infections - AD - STAT3 gene DEFECT IN CHEMOTAXIS

Dumb Shit I Keep Forgetting Flashcards by Alegra Mendez

CD20+

B cells

exception: Reed-Sternberg cells

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CD34+

HSC

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CD38+

lymphoid lineage

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CD33+

myeloid lineage

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CD56+

NK (lymphoid)

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CD13+

granulocytes

monocytes

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t(14;18)

BCL-2

Follicular lymphoma

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t(11;14)

Cyclin D1

Mantle cell lymphoma

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t(8;14)

C-Myc

Burkitt’s Lymphoma

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t(3;14)

BCL-6

Diffuse large B cell lymphoma

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indolent NHL

follicular
small lymphocytic lymphoma
marginal zone lymphoma
Waldstrom Macroglob

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aggressive NHL

mantle cell
Burkitts
Diffuse large B cell
HIV associated

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Protein C/S

VIII
V

(8,5)

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AT-III

II, VII, IX, X, XI

2,7,9,10,11

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TFPI

TF:VII complex

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what does thrombin make

fibrin (I), V, VIII, IX, XI, 13

1, 5, 8, 11, 13

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congenital causes of aplastic anemia

1) Fanconi
2) Schwachman-Diamond
3) Dyskeratosis Congenita
4) Amegakaryocytic Thrombocytopenia

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high basophils

CML

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increased monocytes

chronic infection: TB
chronic inflammation: sarcoid
chronic neutropenia
recovery from neutropenia
preleukemia
myeloproliferative syndrome

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CGD test

nitroblue-tetrazolium test (NBT) is NEGATIVE

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Job’s Syndrome

Hyperimmunoglobulin E
recurrent infections
AD
STAT3 gene

DEFECT IN CHEMOTAXIS

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Dohle Bodies

cytoplasmic inclusions, ribosome rich ER

sepsis, G-CSF use

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reticulocyte index

retic count x (pt Hct/40)

RI>2 in pt with anemia if marrow is responding properly

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anemia of chronic disease lab results

decreased serum iron (hidden from bacteria)
Normal/increased ferritin
Decreased TIBC

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B12 stores

years

folate stores

months

B12 absorption

intrinsic factor + distal ileum

folate absorption

duodenum

pernicious anemia

Abs against intrinsic factor -deficiency of B12 hypersegmented giant neutrophils (megaloblastic anemia) dyssynchrony

each mL of packed red blood cells contains ___ iron

1 mg each mL of packed red blood cells contains 1 mg iron

infectious mononucleosis associated with

cold agglutinin disease

epispdic hemolysis, after antibiotics

oxidant induced G6PD

thrombin time

fibrinogen --> fibrin | the activity of thrombin

PAI-1

plasminogen activator inhibitor

neurologic sx in an ill appearing patient

TTP

AML Tx

Cytrabine + Anthracycline

APL Tx

ATRA | ATO

CML Tx

Imatinib

Polycythemia Vera Tx

Phlebotomy hydroxyurea JAK2 inhibitor

essential thrombocythemia Tx

hydroxyurea JAK2 inhibitor aspirin

primary myelofibrosis Tx

HSCT | JAK 2 inhibitor

MDS Tx

HSCT Growth factors Hypomethylating agents Immune modulators del(5q) - Lenolinamide

Hodgkins Tx

ABVD Anthracycline Bleomycin Vinca Dacarbazine

Non-Hodgkins Tx

Radiation + Chemo/ Rituximab CHOP (cyclophosphamide, antracycline, vincristine, prednisone)

HIV associated lymphoma Tx

HAART

CLL Tx

Fludarabine + Rituximab Ibrutinib

Multiple Myeloma Tx

Melphalan Triplet Therapy: IMiD, proteosome inhibitor, dexamethasone

Plasma cell leukemia Tx

Palliative

Light chain amyloidosis Tx

similar to mutiple myeloma melphalan, imid, proteosome inhibitor, dexamethasone

cryoglobulinemia Tx

cold avoidance | plasmapheresis

ovarian cancer

BRCA gene

thyroid cancer

PTEN, RET

colon cancer

APC LKB1 MMR

melanoma

p16 CDKN2 Rb

flow cytometry

CD markers of a cell

IHC

kappa/lambda chains

if thyroid involved, think

radiation

idarucizumab

reversal agent for dabigatran

andexanet alpha

reversal of rivaroxaban (factor Xa inhibitor)

AML favorable

t(8;21) inv(16) t(15;17)

AML unfavorable

11q23 translocation del5 del7

ALL favorable

t(12,21)

ALL unfavorable

t(9;22) t(4;11) 11q23 translocation

ABVD toxicity

A: cardiac B: pulmonary V: neurologic, hematologic D (dacarbazine): hematologic

bimodal distribution

sequential LN involvement

lenalidomide

myeloma, MDS

poor risk factors CLL

Rai stage 3/4 | 17p deletion

5q deletion

MDS Favorable Tx: lenalidomide

Txs that can cause MDS

alkylators | Topoisomerase Tx

interferon

MPN

PSA

early detection

AFP

diagnostic

tumor size

prognostic

ER, HER

predictive

KRAS

predictive

CEA

therapeutic monitor

BRCA

risk stratification

EMA

epithelial membrane antigen carcinomas

CD45

luekocyte common antigen lymphoma

chromogranin, synaptophysin

neuroendocrine tumor

NSE

neuroendocrine tumor

HCG, AFP

germ cell tumor

vimentin

soft tissue sarcoma