UW revision viral arthritis

Question 1

UW. Parvo B19. general symptoms in most patients?

Answer 1

asymptomatic or flulike

Question 2

UW. Parvo B19. symptoms in children?

Answer 2

Erythema infectosum (fifth disease) = fever, nausea and slapped cheek rash.

Question 3

UW. Parvo B19. symptoms in adults?

Answer 3

acute, symetrical polyarticular arthritis (hands, wrists, knees, feet) - resembles RA)

Question 4

UW. Parvo B19. what hematologic?

Answer 4

transient PURE RBC aplasia; aplastic crisis in patients with underlying hematologic disease (eg sickle cell)

Question 5

UW. Parvo B19. Dx of acute infection? 2

Answer 5

B19 IgM antibodies in immunocompetent patients

NAAT for B19 DNA in immunocompromised patients

Question 6

UW. Parvo B19. Dx of previous infection?

Answer 6

B19 IgG antibodies (documents immunity)

Question 7

UW. Parvo B19. Dx of reactivation of previous infection?

Answer 7

NAAT for B19 DNA

Question 8

UW. Parvo B19. arthritis Tx?

Answer 8

Tx symptomatic; resolves within 1-2 months.
Drugs: NSAIDS

Question 9

UW. Parvo B19. Clinical manifestation correlate with anti-parvovirus IgM levels, which may be assayed for diagnostic purposes.

Answer 9

.