Mehlman pharm: Alendr/teripartide/baclofen

Question 1

Alendronate. group?
mechanism?

Answer 1

bisphosphonates

inhibits osteoclasts (HY mechanism)

Question 2

bisphosphonates
inhibits osteoclasts (HY mechanism)?

Answer 2

Alendronate.

Question 3

Alendronate. when used in osteoporosis?

Answer 3

AFTER Ca/Vit D

Question 4

Alendronate.
In NBME buvo pamidronate in case.
Tx for what pathology? lab

Answer 4

pamidronate (not alendronate) show up on 2CK forms for Tx of hypercalcemia (after normal saline is given).

Question 5

Tx of hypercalcemia (after normal saline is given).?

Answer 5

pamidronate

Question 6

Bisphosphonates causing osteonecrosis of the …

Answer 6

jaw

Question 7

Alendronate. HY pathology caused by bisphosphonates?

Answer 7

USMLE wants you to know bisphosphonates cause pill-induced esophagitis. This is
very HY for 2CK forms (K+ supplements also cause esophagitis).

Question 8

pill-induced esophagitis by what medication group?

Answer 8

bisphosphonates

Question 9

What other group apart bisphosphonates cause pill-induced esophagitis?

Answer 9

K+ supplements also cause esophagitis

Question 10

Teriparatide. what group or analogue/mechanism?

Answer 10

N-terminus PTH analogue that can induce bone formation.

Question 11

N-terminus PTH analogue that can induce bone formation?

Answer 11

Teriparatide.

Question 12

Teriparatide.
Even though PTH
causes bone resorption, this agent stimulates osteoblast-mediated bone formation more than it induces RANK-L mediated activation of osteoclasts

Answer 12

.

Question 13

Even though PTH
causes bone resorption, this agent stimulates osteoblast-mediated bone formation more than it induces RANK-L-mediated activation of osteoclasts?

Answer 13

Teriparatide.

Question 14

Teriparatide. in what osteoporosis?

Answer 14

Can be used for severe/advanced osteoporosis.

Question 15

Can be used for severe/advanced osteoporosis.?

Answer 15

Teriparatide.

Question 16

Denosumab. mechanism?

Answer 16

Monoclonal antibody against RANK-L

Question 17

Monoclonal antibody against RANK-L?

Answer 17

Denosumab.

Question 18

Denosumab. can be used in what osteoporosis?

Answer 18

Can be used for severe/advanced osteoporosis.

Question 19

Baclofen. mechanism?

Answer 19

Agonizes GABA B

Question 20

Agonizes GABA B

Answer 20

Baclofen.

Question 21

Baclofen. in what pathology mainly?

Answer 21

classically in multiple sclerosis, but I’ve seen one NBME Q where it’s used for random spasticity in an older dude.

Question 22

Baclofen. main indication?

Answer 22

used for spasticity.

Question 23

Baclofen. IT IS AGONIST!!!!!!! students often make mistake and says it antagonist.

Answer 23

.