UW revision IBD/inflammatory diarrhea

Question 1

Inflammatory diarrhea. Diseases?3

Answer 1

IBD (Crohn, UC)
Invasive infection (Clostrid., Entamoeba histolytica, CMV)

Ischemic colitis - eg sudden hypotension

radiation colitis - eg following protate cancer tx

Question 2

Inflammatory diarrhea. Labs?

Answer 2

Anemia (mixed chronic disease and iron deficiecy) + leukocytosis _ reactive thrombocytosis

Incr. markers: CRP, ESR, fecal calprotectin or lactoferrin

Question 3

Inflammatory diarrhea. stools?

Answer 3

bloddy stools = ocult or gross

Question 4

Inflammatory diarrhea is characterized by ….

Answer 4

Intestinal wall injury

Question 5

Inflammatory diarrhea. Dx?2

Answer 5

Blood inflammatory + stool inflammatory (calprotectin) + collecting infectious diseases.

Colonoscopy - diagnostic confirmation + allows to take biopsy.

Question 6

IBD. Crohn involvement?

Answer 6

Anywhere mouth to anus (especially terminal ileus = pain in RLQ)

perianal disease with rectal sparing

Question 7

IBD. UC involvement?

Answer 7

Rectum (ALWAYS) and colon

Question 8

IBD. Crohn lesions?

Answer 8

Skip lesions

Question 9

IBD. UC lesions?

Answer 9

Continuous lesions

Question 10

Noncaseating granulomas in what?

Answer 10

Crohn disease

Question 11

IBD. Crohn gross findings?

Answer 11

Transmural inflammation
Linear mucosal ulcerations
Cobblestoning, creep fat

Question 12

IBD. UC gross findings?

Answer 12

Mucosal and submucosal inflammation
Pseudopolyps

Question 13

IBD. Crohn CP?

Answer 13

Abdominal pain (RLQ)
Watery diarrhea (bloody if colitis)

Question 14

IBD. UC CP?

Answer 14

Abdominal pain (varying locations)
Bloody diarrhea

Question 15

IBD. Crohn complications?

Answer 15

Fistulae, abscesses
Strictures (bowel obstruction)

Question 16

IBD. UC complications?

Answer 16

toxic megacolon