Mehlman: NASH, Alcoholic hepat, paracetmol, other drugs 11-15 (2) Flashcards

1
Q

NASH. what case in usmle?

A

overweight patient with normal labs or can be mild transaminitis.

tipo 50 proc normal
50 proc mild transaminitis

tipo the condition starts with normal labs then progresses to mild transaminitis.

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2
Q

NASH. underrated diagnosis.
It’s assumed most overweight people have some degree of fatty liver.

A

.

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3
Q

NASH. what other presentation of patient?

A

metabolic syndrome : incr. BMI and Incr. lipids

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4
Q

NASH. Tx? 2

A

exercise (eg treadmill)
normal diet (sto eat stupid junk food).

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5
Q

Alcohol. what labs? classically AST>ALT

A

tipo sako kad ratio 2:1, bet nebutinai.
NBME gali but tik mild transaminitis, eg. both AST and ALT are <100, but ast slightly higher than ALT.

tipo normal skaitosi <50U/l

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6
Q

Alcohol. whan seen on biopsy? cia cj step1.

A

USMLE wants you to know mallory hyaline is seen on biopsy.

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7
Q

Acetaminophen (M). This overdose is most important for USMLE.
antidote?

A

N-acetylcysteine is antidote.

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8
Q

Acetaminophen (M). breakdown of it produces what?

A

Breakdown of acetaminophen produces metabolite called NAPQI that depletes reduced glutathione. The latter normally mops up free radicals / prevents oxidation.

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9
Q

Acetaminophen (M). how long will be asymptomatic?

A

asymptomatic for 24-48h

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10
Q

Acetaminophen (M). what starts/detected after asymptomatic period?

A

then will proceed to get ALT and AST in the tens of thousands + require liver transplant or death.

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11
Q

Acetaminophen (M).
N-acetylcysteine regenerates reduced glutathione.!!!!!

Oxidized glutathione had disulfide bond (-S—S-); reduced glutathione has thiol (-SH).

A

.

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12
Q

Acetaminophen (M). what do immediately once patient with OD present (acutely after administration of this drug)?

A

administer activated charcoal

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13
Q

Other drugs (M). what 6 most important that cause mild transaminitis?

A

Statins and fibrates, methotrexate, lithium, valproic acid, propylthiouracil.

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14
Q

Other drugs (M). eg use one of these 6 drugs –> mild transaminitis –> what to do with dose?

A

ANSWER IS: You do not need to decrease dose.

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15
Q

Other drugs (M). For statins, myopathy is more common than toxic hepatitis (on NBME).

A

.

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