UW revision ADPKD + cocaine use

Question 1

ADPKD. Asymtomatic till what age?

Answer 1

30-40 y/o

Question 2

ADPKD. Initial symptom?

Answer 2

Early disease manifestation is HTN (it occurs when cysts become large and numerous).

Question 3

ADPKD. renal symptoms? 3

Answer 3

Flank pain, hematuria
Palpable abdominal masses (usually bilateral)
CKD

Question 4

ADPKD. why increased hemoglobin?

Answer 4

increased erythropoietin production (possibly from local ischemia around renal cysts).

Question 5

ADPKD. Extrarenal findings?

Answer 5

Cerebral aneurysms
Hepatic and pancreatic cysts
Mitral valve prolapse, Ao regurgitation (cardiac valvular abnormalities)
Colonic diverticulosis
Ventral and inguinal hernias

Question 6

ADPKD. Diagnosis?

Answer 6

Abdominal UG = multiple renal cysts and enlarged kidneys
OR
Abdominal CT

Question 7

ADPKD. As cystic degeneration progresses with age –> progressive renal dysfunction –> end-stage renal disease

Answer 7

.

Question 8

COCAINE. Behavioral features? 4

Answer 8

personality + mood changes
Changes in sleep patterns
Unexplained weight loss
Financial difficulties

Question 9

COCAINE. Reported symptoms? 3

Answer 9

Chest pain
Epistaxis, rhinitis (intranasal use)
Headaches

Question 10

COCAINE. Examination signs? 3

Answer 10

HTH, tachy
Dilated pupils
Psychomotor agitation

Question 11

COCAINE. Emergent complications? 4

Answer 11

Seizures
Acute myocardial ischemia
Ao dissection
Intracranial hemorrhage