Cardio. Valves (08-12) (1) Flashcards
Bicuspid aortic valve. 2 reasons to develop?
sporadically or through autosomal dominant with incomplete penetrance pattern
Most common type of congenital heart disease in adults?
Bicuspid aortic valve
Bicuspid aortic valve. inheritance pattern?
autosomal dominant with incomplete penetrance pattern
Bicuspid aortic valve. presentation depends on what?
on patients age
Bicuspid aortic valve. pathophysiology in younger patients? 2
Valvular leaflet abnormalities or aortic root dilation
Bicuspid aortic valve. in youger, feature and auscultation
This results in isolated aortic regurgitation (this leads to early decrescendo diastolic murmur which begins immediately after A2 which is best heard with the diaphragm of the stethoscope along the left sternal border at the 3rd and 4th intercostal spaces while the patient is sitting up, leaning forward, and holding a breath in full expiration)
Bicuspid aortic valve. pathophysiology in older patients?
calcification of aortic valves due to excessive wear-and-tear
Bicuspid aortic valve. in elderly. feature as a result of pathophysiology?
This leads to aortic stenosis
Bicuspid aortic valve. complications?2
a. Dilation of aortic root or ascending aorta.
–> Leads to aortic aneurysm and dissection.
–> Causes sudden death.
CHRONIC aortic regurgitation.
etiologies? 3
Congenital bicuspid aortic valve
Postinflammatory (eg, rheumatic heart disease, endocarditis)
Aortic root dilation (eg, Marfan syndrome, syphilis)
CHRONIC aortic regurgitation. pathophysiology?
Backflow from aorta into LV –> incr. in what?
incr. LV end-diastolic volume
CHRONIC aortic regurgitation. pathophysiology?
LV initially compensates with eccentric hypertrophy –> incr. in what?
incr. SV&CO
CHRONIC aortic regurgitation. pathophysiology?
Eventual LV dysfunction –> decr in what?
Eventual LV dysfunction –> decr. SV & CO –> heart failure
CHRONIC aortic regurgitation.
what murmur?
Diastolic decrescendo murmur
CHRONIC aortic regurgitation. what pulse findings? 2
Widened pulse pressure (incr. SBP & decr. DBP) findings
Rapid rise-rapid fall (“water-hammer’’) pulsation
CHRONIC aortic regurgitation. what femoral/carotid pulse finding?
Abrupt carotid distension & collapse, “pistol-shot” femoral pulses
CHRONIC aortic regurgitation. murmur kreive?
S1 - S2 decrendo - S1
What pulsus in Ao regurgitation (vs Ao stenosis)?
Pulsus bisferiens
What pulsus in Ao stenosis (vs Ao regurgitation)?
pulsus parvus et tardus
pulsus parvus et tardus in what?
Ao stenosis
Pulsus bisferiens in what?
Ao regurgitation
Pulsus bisferiens. Biphasic pulse. why?
It refers to 2 systolic peaks of the aortic pulse from left ventricular ejection separated by midsystolic dip
Pulsus bisferiens. in what 3 pathologies?
a. Aortic regurgitation
b. Hypertrophic cardiomyopathy
c. Large PDA
Aortic stenosis. what size area?
<3 cm2
Aortic stenosis. what size when become symptomatic?
Aortic stenosis becomes symptomatic when valve area <1 cm2
Aortic stenosis. common cause?
Age-related sclerocalcific changes in the aortic valves